Do sleep distubances impact the qualrity of life and cognition similarly in men and women with Parkinson’s disease?
Notice bibliographique
Résumé
Background: Much research has been conducted on the influence of sex-related differences on Parkinson‘s disease (PD). While men are approximately 1.5 to 2 times more likely to develop the disease and exhibit more tremors, rigidity, cognitive decline, and autonomic dysfunctions, women report more postural instability, depression, anxiety, and pain. Despite sleep disturbances being very prevalent in patients with PD, little is known about the differences when it comes to the quality of sleep experienced between men and women and the impact of the differences if any on their quality of life and cognition. Objective: To compare the quality of sleep between men and women with PD and to assess its correlation with the quality of life and cognition according to sex-related differences. Methods: This is a cross-sectional study composed of 73 individuals (50 men and 23 women) diagnosed with idiopathic PD, at a mild to moderate stage, and without cognitive deficits. Quality of sleep was assessed using the Parkinson’s Disease Sleep Scale (PDSS-2), the Pittsburgh Quality of sleep Index (PSQI), and the Epworth Sleepiness Scale (ESS). Individuals scoring above 5 on the PSQI were classified as having "poor sleep." Cognition and quality of life were evaluated using the Montreal Cognitive Assessment (MoCA) and the Parkinson’s Disease Quality of Life Scale (PDQ-39), respectively. A significance level of 5% was adopted for the analyses. The study was approved by the Research Ethics Committee (CAAE: 54383021.8.0000.5231). Results: Regarding sleep classification, 72% of men and 52.2% of women were classified as having poor sleep quality. There was no difference in the total scores of the sleep scales between men and women. The only difference detected was that men had worse scores in the daytime dysfunction domain of the PSQI (p=0.015). In the correlation analysis between sleep and quality of life, there was a moderate correlation between the total PDSS-2 and PDQ-39 in both groups (Men: r=0.66; p< 0.001 - Women: r=0.61; p=0.002), and between the PSQI and PDQ-39 only in men (r=0.46; p=0.001). Concerning daytime sleepiness and the quality of life, there was a moderate correlation between the ESS and PDQ-39 in women (r=0.51; p=0.013) and a weak correlation in men (r=0.37; p=0.007). Regarding cognition, a moderate correlation was observed between the total PDSS-2 and the naming domain of the MoCA in men (r=-0.47; p<0.001) and the total PSQI with the abstraction domain in women (r=0.64; p=0.001). Conclusion: In this study, a difference was observed in the daytime dysfunction domain, with men scoring worse compared to women, indicating the impact of sleep on daily functionality. Additionally, men and women with better quality of sleep exhibited signs of a better quality of life. Finally, regarding cognition, men with better quality sleep performed better in the naming domain, while women with better quality sleep performed better in the abstraction domain.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».