Ventricular Enlargement as a Neuroimaging Endophenotype for Schizophrenia in Familial High-Risk Populations: A Systematic Review
Notice bibliographique
Résumé
INTRODUCTION: Ventricular enlargement is one of the most robust and consistently replicated neuroanatomical findings in individuals with schizophrenia.T his review systematically evaluates the evidence for an association between enlarged ventricular volume and the genetic risk for schizophrenia in individuals with a family history of the disorder. METHODS: A systematic search of PubMed, Google Scholar, Semanthic Scholar, Springer, Wiley Online Library databases was conducted to identify observational studies that used computed tomography or magnetic resonance imaging to compare ventricular volumes among schizophrenia patients, their unaffected first-degree relatives, and healthy controls. The secondary aims of this review are to quantify the magnitude of ventricular volume differences among patients, their unaffected first-degree relatives, and healthy controls; to examine the regional specificity of these changes, particularly in the lateral ventricles, third ventricle, and temporal horns; to synthesize evidence on the clinical and biological correlates of ventricular volume, including its relationship with gray matter deficits, symptom severity, gender, and environmental risk factors; and to critically evaluate the cumulative evidence for ventricular enlargement as a valid endophenotype for schizophrenia. The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Data on study design, participant characteristics, imaging parameters, and quantitative ventricular measurements were extracted. The methodological quality and risk of bias of included studies were assessed using the Newcastle-Ottawa Scale (NOS). RESULTS: Patients with schizophrenia consistently exhibit significantly larger lateral and third ventricles and a higher ventricle-to-brain ratio compared to both healthy controls and their unaffected first-degree relatives. Unaffected relatives frequently demonstrate intermediate ventricular volumes, which are larger than those of healthy controls but smaller than those of their affected family members. Secondary outcomes indicate that ventricular enlargement is significantly associated with widespread cortical gray matter deficits, is more pronounced in males, and may be exacerbated by environmental factors such as substance use and obstetric complications in genetically vulnerable individuals. CONCLUSION: A significant and robust association exists between enlarged cerebral ventricular volume and the genetic risk for schizophrenia. This solidifies the status of ventricular enlargement as a key neurobiological marker of liability, for developing multimodal models for early risk identification.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,006 | 0,007 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,003 | 0,001 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».