CPX-351 versus venetoclax plus hypomethylating agents for newly diagnosed acute myeloid leukemia: A systematic review and meta-analysis
Notice bibliographique
Résumé
Abstract Introduction: Acute myeloid leukemia (AML) is one of the most common types of acute leukemia. Since the median age at diagnosis is 68 years, selecting an appropriate treatment strategy is important for older adults who are ineligible for standard 7+3 regimen. Recently, CPX-351 demonstrated superior overall survival (OS) compared to standard 7+3 chemotherapy in older adults with secondary AML, while the combination of venetoclax and azacitidine has shown greater efficacy than azacitidine alone in older adults with AML. However, in real-world clinical practice, it remains unclear which regimen is more appropriate for this population. To address this uncertainty, we conducted a systematic review and meta-analysis to compare the effectiveness of these treatment strategies in patients with AML. Methods: We performed a systematic review and meta-analysis of observational and randomized controlled trials comparing the outcomes in patients with newly diagnosed AML who received CPX-351 versus the combination of venetoclax and hypomethylating agents (Ven/HMA). A comprehensive search of PubMed, Scopus, and Cochrane CENTRAL databases was performed up to June 2025, as well as a manual review of reference lists from relevant articles. This review adheres to the recommendations from the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement guidelines. R software version 4.5.1 was used for statistical analyses. Results: A total of 1,807 patients from nine retrospective studies were included in this systematic review and meta-analysis, comprising 692 patients in the CPX-351 cohort and 1,115 patients in the Ven/HMA cohort. The median age was 64.5 years in the CPX-351 cohort and 73 years in the Ven/HMA cohort. The proportion of patients with AML with myelodysplasia-related changes was 58.1% (n = 393) in the CPX-351 group and 37.8% (n = 396) in the Ven/HMA group. Therapy-related AML accounted for 20.6% (n = 96) of patients in the CPX-351 cohort and 16.8% (n = 138) in the Ven/HMA cohort. Patients classified as favorable or intermediate risk according to the European LeukemiaNet 2017 risk stratification accounted for 29.2% (n = 203) in the CPX-351 cohort and 23.5% (n = 269) in the Ven/HMA cohort. Two studies provide the result of multivariate analyses for OS. As a result, the pooled hazard ratio (HR) favored CPX-351 for OS, but this difference did not reach statistical significance (HR 0.88; 95% CI 0.75-1.03; p = 0.1195; I2 = 0.0%). There was no significant difference in the rates of complete remission (CR) or complete remission with incomplete count recovery (CRi) between the two groups (odds ratio [OR] 0.83; 95% CI 0.58-1.18; p = 0.295; I² = 52.6%). Conclusions: In patients with newly diagnosed AML, CPX-351 did not demonstrate superiority over Ven/HMA in terms of CR/CRi rates. While OS appeared to favor CPX-351, the difference was not statistically significant and we could not reject the null hypothesis. These findings, especially the trend toward improved OS with CPX-351, underscore the need for further prospective studies to more clearly identify the optimal induction therapy for older adults with AML.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,011 | 0,025 |
| Méta-épidémiologie (sens strict) | 0,003 | 0,001 |
| Méta-épidémiologie (sens large) | 0,018 | 0,037 |
| Bibliométrie | 0,005 | 0,006 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,003 | 0,002 |
| Science ouverte | 0,002 | 0,001 |
| Intégrité de la recherche | 0,002 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».