Real-world treatment patterns and patient characteristics of venetoclax combination time-limited therapy for chronic lymphocytic leukemia
Notice bibliographique
Résumé
Abstract Background The use of targeted therapies, such as combinations of anti-CD20 monoclonal antibodies and BCL2 inhibitors, is rapidly evolving in the treatment of chronic lymphocytic leukemia (CLL). Venetoclax plus obinutuzumab (VO) is approved as a first-line (1L) therapy with a fixed 12-month duration, while venetoclax plus rituximab (VR) is approved for second-line and later (2L+) treatment over a 24-month period. This study aims to evaluate real-world utilization and treatment patterns of venetoclax-based combination regimens across distinct lines of therapy in patients with CLL. Methods The IntegraConnect PrecisionQ Database, containing electronic health records from 3 million deidentified community oncology patients in the United States, was used to create a retrospective cohort of CLL patients who initiated venetoclax, stratified by 1L and 2L+ based on the FDA approval date of each combination regimen and duration of the time-limited therapy. Patients receiving 1L V-based therapies were identified from 15 May 2019 to 28 Feb 2024, and patients receiving 2L+ V-based therapies were identified from 08 Jun 2018 to 28 Feb 2023. All patients were followed through 28 Feb 2025. Descriptive analyses were used to identify treatment patterns (e.g. duration of therapy and frequency of use) and baseline characteristics were examined including age, gender, race, Eastern Cooperative Oncology Group performances status (ECOG PS), and comorbidities. Results A total of 1590 and 1456 pts were identified at 1L and 2L+, respectively. The most common venetoclax-based regimens were VO in 1L (61.4%); VR and VO in 2L+ (24.9% and 21.1%). Median age of patients who received venetoclax in 1L and 2L+ was 70 yrs (IQR: 63-77) and 73 yrs (IQR: 66-79), respectively. In 1L, however, VO was used by more patients who were younger (age <70 vs 70+: 64.3% vs 58.7%) and male (male vs female: 63.0% vs 58.4%). Use of VO and VR also differed between White and African American patients in 1L (72.4% vs 66.8%) and 2L+ (5.4% vs 7.2%), respectively. ECOG PS was better in 1L than 2L+ (PS 0, 1, ≥2: 49.9%, 42.2%, 7.9% vs 41.0%, 46.5%, 12.4%), and baseline comorbidity differences were observed between 1L and 2L+: anemia (73.0% vs 79.6%), thrombocytopenia (69.9% vs 76.0%), leukopenia (40.8% vs 35.9%), transaminitis (18.7% vs 26.6%), and atrial fibrillation (5.0% vs 9.3%). Median treatment duration for 1L VO was 15.2 months; 2L+ VR was 22.8 months; 2L+ VO was 17.0 months. However, among patients who had 1L VO treatment, 70.6% received therapy for longer than the recommended 12 months; many patients remained on therapy for an additional year, as only 57.4% discontinued treatment by 24 months. For those who had 2L+ VR, 48.0% received therapy longer than the recommended 24 months, and 52.3% discontinued treatment by 36 months. Conclusions In the US community oncology setting, there are baseline demographic and clinical differences in CLL venetoclax use between 1L and 2L+. VO is commonly utilized in both 1L and 2L+, and many patients remain on 1L VO and 2L+ VR for an extended period beyond the recommended, fixed treatment duration. Real-world venetoclax-based time-limited treatment utilization in CLL appears longer than observed in clinical trials or indicated per label. Future research may explore reasons for these differences.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».