Abstract B013: Epidemiology of early-onset gastrointestinal cancers in Nepal: A scoping review
Notice bibliographique
Résumé
Abstract Introduction: The incidence of early-onset gastrointestinal cancers (EO-GICs, diagnosed <50 years) is rising globally. Low- and middle-income countries such as Nepal face distinct exposures that might influence the disease patterns in younger populations. However, systematic evidence on EO-GICs in these settings is limited. This scoping review aimed to map the available evidence on EO-GICs from Nepal and identify gaps to guide future research and early detection strategies. Methods: This scoping review adhered to the PRISMA-ScR guidelines. Eligible studies included observational studies reporting on patients younger than 50 years with gastrointestinal malignancies (esophageal, gastric, colorectal, hepatobiliary, pancreatic, or gallbladder cancers) in Nepal, while secondary data articles and case reports were excluded. Databases searched included PubMed, NepJol, and relevant grey literature. Reference lists of included articles were also screened. After duplicate removal, titles and abstracts were independently screened by two reviewers, followed by full-text review. Data were synthesized descriptively in narrative formats. Results: A total of 17 hospital-based studies from Nepal were included among 39 records. The colorectal cancer burden was increasing among young adults, with approximately 28% of cases in patients ≤40 years (mean age 31.8-34.1 years). Gastric cancer predominantly affected older adults (mean age 57-63 years), yet 10-22% were under 50. Early-onset gastric cancer cases showed a female predominance and often presented at an advanced stage. Esophageal cancer was most frequent in patients aged 61-70 years (34%); however, 20% were diagnosed before 50 years. Hepatocellular carcinoma affected mainly middle-aged to older adults (mean ages 54-67 years), with 8-26% of cases in younger individuals. Linked risk factors included male sex, viral hepatitis, alcohol use, and cirrhosis; late-stage diagnosis was common. Gallbladder and biliary tract cancers presented in middle-aged adults (mean age 53-56 years), typically presenting at advanced stages, with associated risk factors including gallstones, high parity, early menarche, Terai/Madhesi and Janajati ethnicity, alcohol and pesticide exposure, and low fruit/vegetable intake. Conclusions: Early-onset gastrointestinal cancers in Nepal constitute a significant proportion of the cancer burden, particularly for colorectal and gastric cancers, with younger patients often presenting with distinct clinical features. However, the scarcity of population-based data, national screening programs, and large cohort studies highlights critical knowledge gaps that must be addressed to inform early detection strategies, risk stratification, and targeted interventions in this population. Citation Format: Saroj GC, Bishal Paudel. Epidemiology of early-onset gastrointestinal cancers in Nepal: A scoping review [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: The Rise in Early-Onset Cancers—Knowledge Gaps and Research Opportunities; 2025 Dec 10-13; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(23_Suppl):Abstract nr B013.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,009 | 0,042 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,004 | 0,004 |
| Bibliométrie | 0,022 | 0,019 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,004 | 0,005 |
| Science ouverte | 0,002 | 0,003 |
| Intégrité de la recherche | 0,002 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,009 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».