Abstract B031: Clinicopathologic features associated with metastatic early-onset gastric cancer
Notice bibliographique
Résumé
Abstract Background: The incidence of metastatic gastric cancer among young adults is rising and has a dismal prognosis with 5-year survival of only 4%. Little is known about the clinicopathologic features associated with metastatic vs locoregional disease in young adults compared to older adults. Methods: This retrospective case control study evaluated patients treated for gastric cancer at USC Norris Comprehensive Cancer Center and LA General Hospital from 2000-2022. Sociodemographic characteristics, clinical presentation and tumor features were compared for early-onset (EO; age <50 years) cases and typical onset (TO; >50 years) controls in a 1:2 ratio matched by diagnosis year and facility. All analyses were performed within matched sets, with three samples per set. Using conditional logistic regression to estimate odds ratios, the pooled analysis tested whether there is an association between sociodemographic, clinical and tumor characteristics and metastatic vs locoregional presentation in aggregate. The early versus older onset analysis examined whether these associations differ by onset type, in terms of either the direction or the magnitude of the association. Results: 795 patients were evaluable (265 EO, 530 TO). Hispanic patients are more likely to present with metastatic disease compared to Asian (OR=2.22, 95%CI 1.34-3.70, p=0.002). Non-Hispanic White are more likely to present with metastatic disease compared to Asian (OR=2.97, 95%CI 1.61-55.48, p<0.001). This association did not differ by EO vs TO. There was no difference in stage at presentation by sex, BMI, primary location of tumor or H. pylori status of the tumor. Overall, patients with intestinal histologic compared to diffuse histologic characteristics are less likely to present with metastatic disease (OR=0.30, 95%CI 0.11-0.85, p=0.023). This association does not differ between EO and TO (p=0.48). There was no difference in the association between MSI status and metastatic disease by EO vs TO (p=0.54). Patients with HER2 amplified status are more likely to present with metastatic disease compared to patients with non-amplified HER2 (OR=2.97, 95%CI 1.25-7.09, p=0.014); however, there was no difference in risk between EO vs TO (p=0.87). Patients with a negative endoscopy prior to diagnosis (16% EO, 18% TO) were equally likely to present with locoregional or metastatic disease (p=0.91). There was no difference in association between metastatic disease and smoking or alcohol use (p=0.069, p=0.64 respectively). Conclusions: Early detection of gastric cancer, especially in non-Asian communities, is crucial as they are more likely to present with metastatic disease. The similarities in disease presentation and characteristics between early vs older onset patients suggests unmeasured environmental exposures may be associated with adverse biological features driving the rising incidence of metastatic disease in young adults. Deeper molecular characterization of metastatic vs locoregional patients may identify other factors contributing to poor outcomes. Citation Format: Jessica Sheth Bhutada, Fox Bravo, Maureen Cairns, Qi Nie4, Ruopei Wu, Danielle Estell, Arthur Bookstein, Justine Po, Myles Cockburn, Chanita Hughes Halbert, Syma Iqbal, David Freyer. Clinicopathologic features associated with metastatic early-onset gastric cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: The Rise in Early-Onset Cancers—Knowledge Gaps and Research Opportunities; 2025 Dec 10-13; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(23_Suppl):Abstract nr B031.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».