Abstract B022: Trends in the Cumulative Incidence of Second Primary Cancers Among Survivors of Early-Onset Cancer in the United States, 1975-2022
Notice bibliographique
Résumé
Abstract Introduction: Survivors of a first primary cancer (FPC) have a higher risk of developing a second primary cancer (SPC) compared to the general population, potentially driven by shared etiologic factors, genetic susceptibility, treatment-related effects, or heightened surveillance and screening. However, this elevated risk has not been well-characterized in the context of the rising incidence rate of adult early-onset cancers. Methods: Using data from 9 cancer registries in the U.S. from 1975 to 2022 in the Surveillance, Epidemiology, and End Results (SEER) Program, we estimated 5-year cumulative incidence of invasive SPC among those diagnosed with invasive FPC and the average annual percent change (AAPC) by age at FPC diagnosis (18-29, 30-49, 50-59, 60-69, 70-79, 80+), and examined these trends by sex and race/ethnicity. Results: Among FPC survivors, the age-standardized 5-year cumulative incidence of SPC steadily increased from 4.10 [3.90, 4.29]% to 6.54 [6.38, 6.69]% with AAPC of 1.12 [1.03, 1.20]% during the study period. The cumulative incidence increased across all age groups at FPC diagnosis. Among early-onset cancer survivors (i.e., those with FPC diagnosis at age 18-49 years old), female individuals had a higher SPC cumulative incidence than male individuals over the study period. However, the increase over time was steeper among males (e.g., for age 30-49 years old, AAPC: 1.59 [1.20, 1.98]% vs. 0.57 [0.37, 0.78]%), making the cumulative incidences similar in males and females by the end of the study period. Among those with FPC diagnosis at age 30-49 years old, the SPC cumulative incidence increased for all racial/ethnic groups, but the increase was steeper for Hispanic and non-Hispanic (NH) Asian or Pacific Islander (API) individuals compared to NH Black and NH White individuals. Notably, NH API individuals had a higher AAPC at this age group than at older age groups, a pattern unique to this racial/ethnic group. Among those with FPC diagnosis at age 18-29 years old, the trends were inconsistent across racial and ethnic groups, with positive AAPC for NH White individuals (1.93 [1.35, 2.51]%) and negative AAPC for Hispanic individuals (-2.59 [-4.26, -0.89]%). Conclusion: For nearly five decades, the burden of SPC following early-onset cancer has risen steadily across demographic groups. These trends suggest a compounded burden of cancer for more recent generations, who face an elevated risk of both an early-onset first cancer and a subsequent cancer, which may also occur at a young age. Potential drivers of these patterns, including improved survival, harmful treatment effects, and other etiologic factors, should be investigated in future research. Citation Format: Sunyeop Lee, Erica J. Lee Argov, Parisa Tehranifar. Trends in the Cumulative Incidence of Second Primary Cancers Among Survivors of Early-Onset Cancer in the United States, 1975-2022 [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: The Rise in Early-Onset Cancers—Knowledge Gaps and Research Opportunities; 2025 Dec 10-13; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(23_Suppl):Abstract nr B022.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».