Systematic review of neuroimaging findings in children and young adults with chronic kidney disease
Notice bibliographique
Résumé
BACKGROUND: Chronic kidney disease (CKD) is associated with poorer neurocognitive outcomes. Neuroimaging studies have been mostly undertaken in older adults. However, individuals under 25 are uniquely impacted due to concurrent brain development. AIMS: This systematic review explored neuroimaging in children and young adults with CKD aiming to characterize brain outcomes in paediatric CKD. METHODS: A systematic search of MEDLINE Ovid, EMBASE and Cochrane databases was undertaken on October 10, 2024. Observational studies involving patients with CKD aged 0-25 years and having neuroimaging findings as a key outcome were included. Following quality assessment using the Newcastle-Ottawa scale, a narrative review was performed. RESULTS: Sixteen studies were included: 737 individuals across studies. Smaller brain volumes were reported in three of five studies (with one contradictory). White matter integrity was impaired, even in patients with mild disease. The latter was associated with a lower intelligence quotient. Silent brain infarcts were identified in up to 79% of dialysis patients with associations with markers of bone disease, longer dialysis duration and haemodynamic instability. Brain regions involved in attention, executive functions and the resting-state network demonstrated abnormal connectivity that was associated with longer reactivity and a response time in visual memory task. Measures of anaemia were inversely associated with increased cerebral blood flow (CBF) which corresponded with poorer verbal memory. CONCLUSION: Neurodevelopment is altered in paediatric CKD. Although a global mechanism for this remains unclear, it is evident that even early CKD is associated with increased risk of brain damage and cognitive deficits. Treatment methods and duration, disease severity and blood calcium and parathyroid concentrations were strongly associated with brain injury. Future work should prioritize longitudinal models of assessment with a focus on recruitment of uniform groups based on age, disease severity, aetiology and treatment to more clearly delineate the effects of disease on neurodevelopment.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,004 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».