Regenerative Therapy in Osteoarthritis Using Umbilical Cord‐Origin Mesenchymal Stem Cells: A Critical Appraisal of Clinical Safety and Efficacy Through Systematic Review and Meta‐Analysis
Notice bibliographique
Résumé
Introduction Recent decades have witnessed a high prevalence of knee osteoarthritis among adults, which is associated with chronic pain, functional limitations, and decreased quality of life. Given the ineffectiveness of conventional cartilage regeneration approaches, umbilical cord‐derived mesenchymal stem cells (UC‐MSCs) have emerged as a potential regenerative therapy. In this study, it was aimed to determine whether UC‐MSC treatment for knee osteoarthritis is effective, safe, and what is the optimal dosage to achieve optimal outcomes. Methods This study was conducted as a systematic review and meta‐analysis based on the PRISMA 2020 guideline. The dose of cells was divided into four groups: less than 25 × 10 6 (low), 25–50 × 10 6 (medium), more than 50 × 10 6 (high), and cases with no dose reported. An extensive search was conducted in PubMed, Embase, Scopus, Web of Science, ClinicalTrials.gov, and other sources up to September 2025. Randomized, phase I/II, and quasi‐experimental clinical trial studies that used UC‐MSCs in human patients with osteoarthritis were included in the analysis. Cochrane RoB and ROBINS‐I tools were used to assess the quality of studies, and statistical analysis was performed using RevMan 5.4. Results Of the 1427 identified articles, 8 studies with a total of 688 participants were finally included in the systematic review and meta‐analysis. Although the analysis indicated that intra‐articular injections of UC‐MSCs reduced pain intensity (visual analog scale [VAS]) at both 6 months (standardized mean difference [SMD]: −0.86; 95% CI: −2.41 to 0.69; p = 0.28) and 12 months (SMD: −1.02; 95% CI: −2.62 to 0.58; p = 0.21), the observed reductions were not statistically significant. Notably, a subgroup analysis revealed that administration of a low‐dose UC‐MSC formulation resulted in a statistically significant reduction in pain scores at both 6 and 12 months ( p ≤ 0.0001). In addition, there was also an improvement in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score at 6 months (SMD: −25.81; 95% CI: −45.15 to −6.46; p = 0.009) compared to control. Compared to high‐dose groups or control interventions (e.g., hyaluronic acid or placebo), low and medium doses (less than 25 × 10 6 and 25–50 × 10 6 million cells) demonstrated a superior efficacy. No serious treatment‐related adverse events were reported, and the adverse events were mild, transient, and manageable. Conclusion UC‐MSC treatment in patients with knee osteoarthritis is a safe and effective method for improving pain and motor function, and it represents a promising alternative to traditional treatments. Given the promising results of this study, further prospective studies with a standardized design and economic evaluations are recommended to enable wider clinical application of this method.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,003 | 0,001 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».