Learning and applying research skills in order to transfer them in different clinical settings: prospective cohort studies to build research capacity
Notice bibliographique
Résumé
The research work here presented was conducted with the aim of developing and transferring the skills and methodologies required to promote and enhance operational research capacity in differently resourced health care settings. The program has been built on three different intertwining components: first, theoretical learning of research methods, with focus on epidemiology and biostatistics; then the application of acquired skills to develop and conduct independent original research in collaboration with international research groups and finally, transferring the research skills either in coordinating and preparing a multicenter study in a resourced-limited setting or in analyzing, reviewing and editing works of other researchers. The present thesis includes a summary of the competencies acquired at university of Padova and at the Harvard School of Public Health, reports the original research carried out by the candidate during the program and outlines the research activities in which the candidate was involved as coordinator and collaborator, The three original research works were cohort studies (prospective or retrospective) on infectious disease epidemiology or progression (HIV and gastroenteritis). The first and main original research work was a survival study realized on a multicenter cohort of HIV patients in a low-middle income country (Thailand) with an international research group. This prospective cohort’s objective was to estimate survival at 5 years for patients with HIV treated with antiretroviral treatment (ART) and to identify the risk factors for mortality occurring immediately after starting ART (early mortality, defined as <6 months) and later during follow-up (long-term mortality, defined as >6 months). The rationale was that in resource limited settings, while early mortality is known to be high and caused by advanced disease status at the time of treatment initiation, much less is known on magnitude and predictors of long-term mortality in these settings. The candidate was involved in data collection, and was responsible for planning the study and its analysis, analyzing the data, interpreting the results and composing the corresponding paper and poster. The second work was the analysis of a multicenter prospective cohort of HIV patients in Canada. The aim of the study was to identify which variables known at baseline could predict the occurrence of end stage liver disease in patients with HIV/HCV co-infection. The candidate planned the study and its analysis, analyzed the data, interpreted the results and along with co-authors, wrote the corresponding publications . The third work was a retrospective cohort study, aimed to describe the epidemiology and management of a common infectious disease (acute gastroenteritis) at ambulatory facilities in Italy. The role of the candidate was to interpret and discuss results, as well as organize and collaboratively write the final paper. Finally, during this program, the candidate was involved in skill transferring activities: specific aspects of research (for example literature review) for teachers and formal training on epidemiology for medical students in an university in resource limited settings, site investigator and coordinator of a multicenter study on HIV prevention in resources limited settings; collaborating in results interpretation and paper writing with units in a tertiary level hospital (Padova University). In conclusion, in these years of doctoral training, the candidate acquired specific and technical competencies in research methodology, focusing on conducting and planning operational research in differently resourced settings in which medical care is provided. She further demonstrated how effectively her skills could be applied in various research environments, leading to the production of works either published, presented in international conferences or under review for publication. Finally, her skills were transferred to support the inception of new studies, leading to an enhanced research capacity in necessitous environments.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,023 | 0,013 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,003 | 0,004 |
| Études des sciences et des technologies | 0,001 | 0,002 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,004 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».