Abstract 8419: Impact of Abdominal Obesity and Physical Inactivity on the Relationship Between Systemic Hypertension and Risk of Coronary Heart Disease in Apparently Healthy Men and Women
Notice bibliographique
Résumé
Background Individuals with systemic hypertension (HT) are at increased of future coronary heart disease (CHD). Physical inactivity and abdominal obesity may increase the risk of HT and impact on the relationship of HT and CHD risk. Therefore, the objective of the present study was to test the hypothesis that active individuals with smaller waist circumference (WC) will have lower blood pressure (BP) than inactive individuals with higher WC in a large population-based sample of individuals representative of a contemporary European population. Our second objective was to determine the respective contributions of WC and HT to CHD risk. Methods and Results A total of 9580 men and 12250 women aged 45 to 79 years residing in Norfolk, United Kingdom participated in a prospective, population-based study with a 11.4-year follow-up. During follow-up, 2191 CHD events were recorded. Physical activity was evaluated using a validated lifestyle questionnaire that takes into account both leisure-time and work-related physical activity. WC was measured at the smallest circumference between the ribs and iliac crest with a D-loop non-stretch fibreglass tape. BP was measured by using a non-invasive oscillometric device in sitting position. Within each physical activity category, a consistent relationship was observed between increasing WC tertiles and increasing systolic (SBP) and diastolic BP. Within each WC tertile, inactive individuals had higher SBP than active individuals (P for trend <0.001). After adjusting for traditional CHD risk factors, compared to individuals with both low WC and BP, those with high BP and high WC were at increased CHD risk (Hazard ratio (HR) =3.32 [95% CI, 2.25-4.89] and 3.11 [1.98-4.87] respectively in men and women). In individuals with normal BP, those in the top WC tertile were at increased CHD risk compared to those in the bottom WC tertile (HR=2.78 [1.66-4.66] and 2.23 [1.18-4.20] respectively in men and women). Conclusion In this population-based study, elevated WC and HT have an independent and additive impact on CHD risk. Targeting elevated abdominal obesity by increasing physical activity levels may reduce the increased CHD risk associated with elevated BP in primary prevention.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».