Relationship of Cognitive Function with Emotion and Sleep Architecture in Patients with OSAHS
Notice bibliographique
Résumé
Background Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a sleep-related breathing disease,which influences patients' sleep quality and emotion regulation due to long-term intermittent hypoxemia and sleep fragmentation. It has a close relationship with cognitive function. Objective To explore the relationship of cognitive function with emotion and sleep architecture in patients with OSAHS. Methods A retrospective analysis was conducted. Participants were 116 cases of OSAHS diagnosed by polysomnography(PSG) recruited from Sleep Medical Center,Shengjing Hospital of China Medical University from September 2019 to December 2020. Clinical data were collected,including results of PSG and questionnaires before PSG〔including Generalized Anxiety Disorder(GAD-7),Patient Health Questionnaire-9(PHQ-9), Montreal Cognitive Assessment(MoCA),Mean Memory and Executive Screening(MES),Insomnia Severity Index(ISI), Epworth Sleepiness Scale(ESS)〕. According to the total score of MoCA,participants were divided into normal cognition group (≥ 26 points, n=79) and abnormal cognition group (<26 points, n=37). Pearson and Spearman correlation analyses were used to study the correlation of cognitive function with PSG indicators. Multiple linear regression analysisi was used to explore the factors associated with cognitive function. Results There were no significant differences in emotion functions between normal cognition group and abnormal cognition group. Both groups had significant differences in mean age,sex ratio,MES score,total arousals,arousals in non-rapid eye movement(NREM),arousals in rapid eye movement(REM),total sleep time(TST), wake after sleep onset(WASO),sleep efficiency,percentage of stage N3 sleep(N3/TST%) and percentage of REM(REM/ TST%) (P<0.05). Correlation analyses showed that MoCA score was negatively correlated with age,apnea hypopnea index (AHI),and WASO(P<0.05),and positively correlated with TST,sleep efficiency,REM/TST%,total arousals and arousals in REM(P<0.05). The score of delayed recall in the MoCA scale was negatively correlated with age and WASO (P<0.05),and positively correlated with sleep efficiency,REM/TST%,total arousals and arousals in REM(P<0.05).The total score of MES was negatively correlated with age(P<0.05),and positively correlated with REM/TST%,total arousals, and arousals in NREM and REM(P<0.05). Multiple linear regression analysis showed that age,AHI and REM/TST% were associated with MoCA score(P<0.05),and age was associated with delayed recall score and MES score(P<0.05). The final regression model established using stepwise regression revealed that the MoCA score had a stronger correlation with age and REM/ TST%,and MoCA score was negatively correlated with age(P<0.05),and positively correlated with REM/TST%(P<0.05). Conclusion The decline of cognitive function in OSAHS patients was significantly correlated with the reduction of REM. No obvious abnormality in emotion was found in these patients with cognitive dysfunction. The relationship between cognitive function and sleep architecture in OSAHS patients can be further clarified in future research.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».