Intervention of viral infections by targeting host cellular protease A proposition based on viral glycoprotein processing
Notice bibliographique
Résumé
Interdisciplinary School of Health Sciences, Department of Health Science, Chronic Disease Program, Ottawa Hospital Research Institute, U Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada Department of Chemical Engineering, McGill University, Montreal, Canada <em>E-mail</em> : abasa2@uottawa.ca <em>Manuscript received 24 July 2013, accepted 25 July 2013</em> During the past century our world has witnessed a number of global pandemic outbreaks of viral infections from time to time, often with deadly consequences. However, in recent years viral infections of new types or variants are beginning to emerge often with significantly high virulence properties. A number of these new strains are derived from animals such as avian, cattle, primates, etc. which have crossed the animal barrier due to varying reasons that may include the change in lifestyle, food habit, increased migration, globalization as well as living and staying too close to animals. Extensive research has been undertaken to better understand the genetic and protein architectures of these and other highly infectious viruses and their mode of progression. Already potential targets have been identified for development of safe and effective intervention and treatment strategies. <em>\(These\) \(are\) \(all\) \(directed\) \(towards\) \(the\) \(viral \) \(components\) \(such\) \(as\)</em> <em>\(viral\) \(enzyme,\) \(viral\) \(protein\) \(and\) \(viral\) \(membrane\) \(associated\) \(with\) \(the\) \(fusiogenic\) </em>\(event.\) However, host cellular enzyme/s of protease family also plays a critical role in viral pathogenesis and infection. It cleaves viral surface glycoproteins leading to their maturation forms to be recognized by host cellular receptor. This leads to viral fusion with host membrane and delivery of its components leading to viral replication and progression. As a result, these selected host proteases may also be considered as important targets for blockade of viral infection and pathogenesis. In this respect, one enzyme in particular called furin (also known as PCSK3) that belongs to the Proprotein Convertase Subtilisin Kexin (PCSK) super family stands out the most. In fact, furin inhibitors have been developed and shown<em> in vitro</em> and animal models to diminish viral replication and its load. Development of highly selective furin inhibitors is thus an attractive .option to fight against the viral infections despite the challenge one has to face in terms of enzyme specificity, potency and delivery of anti-furin agents in an organ/tissue-specific manner. This review discusses the various issues facing this approach. Both pros and cons of this methodology are discussed and debated in this review.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».