Pourquoi ce travail est dans la base
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Notice bibliographique
Résumé
Cancer develops from normal cells upon the accumulation of mutations. Two majors types of cancer genes are altered in human tumor cells, oncogenes and tumor suppressors. Activation of oncogenes cooperates with inactivation of tumor suppressors to fully transform cells. One of the major tumor suppressor pathways in humans is the so-called RB pathway. RB acts as a cellular brake, when its gene is deleted or when there are alterations in proteins that control RB function, then cells divide abnormally. After nearly three decades of study, the role of the RB pathway in cancer has been well established and inactivation of RB has been found in a large number of human cancers,including lung cancer as well as many cancers associated with cigarette smoking. Research on RB remains intense with publication of nearly 1,000 relevant journal articles a year, but major challenges in the RB field include determining the different roles of the multiple RB-containing complexes in cells, exploring the importance of novel biological functions for RB and their relationship to tumor suppression, as well as identifying novel therapeutic approaches to stop or slow the growth of human tumor cells with mutations in the RB pathway. In particular, because RB is not an enzyme, there are no simple ways to inhibit its activity in cells; in addition, RB controls the expression of a large number of other genes and it is unclear which function of RB is important for the inhibition of cancer. One major hurdle in the RB field has been the lack of scientific interactions between members of this community. While some RB researchers sometimes meet at scientific conferences focusing on cancer or cell cycle, these conferences often have a limited number of presentations on RB and its pathway. With this in mind, Drs. Zacksenhaus and Bremner organized the first two International RB meeting in 2009 and 2011 in Toronto. The meetings were deemed a success and help solidy a large group of investigators with a strong interest in participating in a scientific meeting focusing on RB and its regulatory networks, which would be organized every other year in a rotating manner by active participants. The 2013 meeting will be co-organized by Dr. Sage (PI, Stanford University, CA) and Dr. Seth Rubin (co-PI, UC Santa Cruz, CA). The major goal of this meetign will be to enhance the opportunities to exchange ideas between researchers in the field, incluidng by presenting recent and unpublished data. Having the meeting in Monterey will help recruit new investigators to the field and the conference and will raise the visibility of research being conducted in California on lung cancer and other cancers associated with cigarette smoking.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,003 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,227 | 0,031 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle