Alcohol-related cognitive impairment: neuropsychological findings and cognitive assessment in a clinical context
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Notice bibliographique
Résumé
Background: It is well established that chronic alcohol consumption can detrimentally impact brain structure and function. In the clinical setting, however, diagnosis of alcohol-related cognitive impairment (ARCI) is frequently complicated by the presence of comorbid psychiatric and health conditions. It is unclear which neuropsychological tasks best detect cognitive impairment in alcohol use disorder (AUD) samples in which these comorbid conditions are present. Aims: The research included in the current thesis was designed to provide clinically useful findings regarding the neuropsychological features of ARCI, including the presentation of ARCI in individuals with comorbid conditions. Method: A systematic review of the literature was conducted to examine the neuropsychological profile of two alcohol-related cognitive disorders: alcohol-related dementia and Korsakoff syndrome. In addition, two empirical studies were conducted. In the first, a neuropsychological battery was administered to 21 participants diagnosed with AUD and a control group matched on age, education and gender. Statistical comparisons between groups on cognitive tasks were performed. In the second, the diagnostic accuracy of the Mini Mental State Examination (MMSE), Addenbrooke's Cognitive Examination-Revised (ACE-R), and the Montreal Cognitive Assessment (MoCA) in detection of cognitive impairment was examined. This was evaluated in 30 individuals with substance use disorder diagnoses and 20 healthy controls using the receiver operating characteristic method. Results: The results of the systematic review demonstrated the heterogeneity in methodological approaches, which preclude definitive conclusions being drawn regarding the neuropsychological profile of alcohol-related cognitive syndromes. The results of the first empirical study confirmed the high rates of comorbid psychiatric, neurological and health conditions that accompany individuals with AUD. Participants in the AUD group were most frequently impaired in the delayed memory domain, while semantic fluency and visuospatial memory tasks best distinguished the AUD group from controls. In the second empirical study, it was demonstrated that the ACE-R and the MoCA had superior discriminative qualities to the MMSE in the detection of cognitive impairment in the substance use sample. It was concluded that further validation of cognitive tasks appropriate for assessment of the SUD population is necessary in future research.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle