Additional file 1 of Rapidly improving ARDS differs clinically and biologically from persistent ARDS
Notice bibliographique
Résumé
Additional file 1. Figure E1. Study Design. All patients were enrolled in the Early Assessment of Renal and Lung Injury (EARLI) cohort from November 2008 to May 2018. We analyzed data from 215 patients who met Berlin criteria for ARDS on day 1 or 2 of the study, were endotracheally intubated at the time of meeting Berlin criteria, and had plasma biomarker measurements available. Patients met criteria for rapidly improving ARDS if any of the following criteria were met: (i) Pao2:Fio2 > 300 or (ii) Spo2:Fio2 > 315 on the day following diagnosis of ARDS (day 2) or (iii) unassisted breathing by day 2 and for the next 48 hours (defined as absence of endotracheal intubate on day 2 through day 4). Table E1. Comorbidities were compared in patients with RIARDS versus persistent ARDS. Cirrhosis was more commonly identified in persistent ARDS. Other comorbidities were not significantly different between each group. Table E2. Concomitant medical conditions were compared in patients with RIARDS versus persistent ARDS. Hypertensive crisis at time of enrollment was more common in patients with RIARDS compared to those with persistent ARDS. Table E3. Type of steroids administered over the first 48 hours of ARDS diagnosis in patients with RIARDS compared to those with persistent ARDS. Table E4. Sensitivity analysis focused on patients with severe ARDS (defined by a PaO2:FiO2 equal to or less than 100 at time of enrollment). Vasopressor-dependent shock was more commonly seen in patients with severe persistent ARDS compared to severe RIARDS. Hospital mortality was significantly higher while ICU-free days was lower in those with severe persistent ARDS compared to severe RIARDS. Table E5. Sensitivity analysis focused on patients with severe ARDS. Patient comorbidities did not differ significantly between RIARDS and persistent disease among those with severe ARDS. Table E6. Sensitivity analysis focused on patients with severe ARDS. Concomitant medical conditions did not differ significantly between RIARDS and persistent disease among those with severe ARDS. Table E7. Sensitivity analysis focused on patients with severe ARDS. Ventilatory parameters did not differ significantly between RIARDS and persistent disease among those with severe ARDS. Table E8. Sensitivity analysis focused on patients with severe ARDS (defined by a PaO2:FiO2 equal to or less than 100 at time of enrollment). Plasma inflammatory biomarkers were significantly higher in those with severe persistent ARDS compared to severe RIARDS. Table E9. Sensitivity analysis comparing RIARDS and persistent disease among cases allocated to the hyperinflammatory phenotype. Similar to the results seen in the overall cohort, compared to patients with hyperinflammatory persistent ARDS, patients with hyperinflammatory RIARDS had significantly lower in-hospital mortality at 28 days and higher ICU-free days. However, contrary to results seen in the overall cohort, vasopressor-dependent shock on day 1 was equally prevalent. Severe hypoxemia was more commonly seen in persistent ARDS and not appreciated in RIARDS. Table E10. Sensitivity analysis comparing RIARDS and persistent disease among cases allocated to the hyperinflammatory phenotype. Microbiology and medications received did not differ between each group. Table E11. Sensitivity analysis comparing RIARDS and persistent disease among cases allocated to the hyperinflammatory phenotype. No significant differences were found in plasma inflammatory biomarker concentration between patients with RIARDS and persistent ARDS. Table E12. Total counts of missing values. Ventilatory parameters stratified by persistent ARDS versus RIARDS. Table E13. Total counts of missing values. Biomarkers stratified by persistent ARDS versus RIARDS. Table E14. Total counts of missing values. Comorbidities and concomitant medical conditions stratified by persistent ARDS versus RIARDS.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,045 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,002 | 0,004 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,002 | 0,002 |
| Science ouverte | 0,002 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,707 | 0,044 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».