Additional file 1 of Association of sepsis-induced cardiomyopathy and mortality: a systematic review and meta-analysis

Additional file 1: Appendix Table S1. Search strategy in PubMed and Embase on 8 July 2021. Appendix Table S2. Appraisal of cohort studies and case-control studies with Newcastle Ottawa Scale. Appendix Table S3. Risk estimates of the included studies. Appendix Table S4. Risk adjustment method of the included studies for data pooling. Appendix Table S5. One-by-one exclusion method for subgroup analysis of in-hospital mortality. Appendix Table S6. One-by-one exclusion method for sensitivity analysis of one-month mortality. Appendix Table S7. A random-effects meta-regress with Egger's regression-based test for the in-hospital mortality. Appendix Table S8. A random-effects meta-regress with Egger's regression-based test for the one-month mortality. Appendix Figure S1. The forest plot of the total selected studies 1. Mortality during ICU stay; 2. Mortality within 7 days; 3. Mortality within 10 days; 4. One-month mortality; 5. In-hospital morality; 6. One-year mortality; 7. Two-year mortality; 8. Mortality with non-defined duration. Appendix Figure S2. Sensitivity analyses of in-hospital mortality. Using the data for left ventricular diastolic dysfunction in Vallabhajosyula et al. 2016. Appendix Figure S3. Sensitivity analyses of in-hospital mortality. Using the data for left ventricular diastolic and diastolic dysfunction in Vallabhajosyula et al. 2016, with the assumption of no duplicated patients. Appendix Figure S4. Sensitivity analysis for in-hospital mortality. Due to the possibility of duplicated patients, the sensitivity analysis excluded anyone study of Vallabhajosyula to evaluate the range of result uncertainty. (upper, excluding Vallabhajosyula, 2017; lower, excluding Vallabhajosyula, 2018). Appendix Figure S5. Subgroup analysis for in-hospital mortality. The selected studies were divided into sepsis diagnosis with sepsis II and sepsis III definitions. (1, sepsis II; 2, sepsis III). Appendix Figure S6. Subgroup analysis for in-hospital mortality. The selected studies were divided into Day-1, Day-2, Day-3 echocardiography screening. (1, Day 1; 2, Day 2; 3, Day 3). Appendix Figure S7. Subgroup analysis for in-hospital mortality. The selected studies were divided into echocardiography by protocol and by clinical needs. (1, by protocol; 2, by clinical needs). Appendix Figure S8. Subgroup analysis for in-hospital mortality. The selected studies were divided into the subgroups according to (1) left ventricular systolic dysfunction, (2) left ventricular diastolic dysfunction, (3) left ventricular dysfunction, (4) right ventricular dysfunction. Appendix Figure S9. Subgroup analysis for in-hospital mortality. The selected studies were divided into the subgroups according to different cut-off values. 1. Only LVEF <50%, 2. LVEF<50%, or LVEF reduction >10%, 3. LVEF<50%+E/e’>15, 4. RV S’ <15cm/s or TAPSE <16mm. Appendix Figure S10. Subgroup analysis for in-hospital mortality. The selected studies were divided into the subgroups according to whether the risk estimate adjustment was performed in the selected studies. (1, without risk estimate adjustment; 2, with risk estimate adjustment). Appendix Figure S11. Subgroup analysis for in-hospital mortality. The selected studies were divided into the subgroups according to the appraisal quality of studies (1. Worse quality; 2. Better quality). Appendix Figure S12. The bubble plot diagrams showed the meta-regression examining the heterogeneity in in-hospital mortality by different characteristics in the selected studies. Appendix Figure S13. Sensitivity analyses of one-month mortality. Using the data for right ventricular dysfunction in Innocenti’s study. Appendix Figure S14. Sensitivity analyses of one-month mortality. Using the data for left and right ventricular dysfunction in Innocenti’s study Innocenti’s data (assumed no duplicated patients). Appendix Figure S15. Sensitivity analysis for one-month mortality. Due to the possibility of duplicated patients, the sensitivity analysis excluded anyone study of Innocenti to evaluate the range of result uncertainty. (upper, excluding Innocenti, Mar 2020; lower, excluding Innocenti, Oct 2020). Appendix Figure S16. Subgroup analysis for one-month mortality. The selected studies were divided into sepsis diagnosis with sepsis II and sepsis III definitions. (1, sepsis II; 2, sepsis III). Appendix Figure S17. Subgroup analysis for one-month mortality. The selected studies were divided into Day-1, Day-2, Day-3 echocardiography screening. (1, Day 1; 2, Day 2; 3, Day 3). Appendix Figure S18. Subgroup analysis for one-month mortality. The selected studies were divided into echocardiography by protocol and by clinical needs. (1, by protocol; 2, by clinical needs). Appendix Figure S19. Subgroup analysis for one-month mortality. The selected studies were divided into the subgroups according to (1) left ventricular systolic dysfunction, (2) left ventricular diastolic dysfunction, (3) left ventricular dysfunction, (4) right ventricular dysfunction, (5) left and right ventricular dysfunction. Appendix Figure S20. Subgroup analysis for one-month mortality. The selected studies were divided into the subgroups according to different cut-off values. 1. Only LVEF <50%, 2. LVEF<50% or LVEF reduction >10%, 3. LVEF<50%+E/e’>15, 4. RV S’ <15cm/s or TAPSE <16mm. Appendix Figure S21. Subgroup analysis for one-month mortality. The selected studies were divided into the subgroups according to the appraisal quality of studies (1. Worse quality; 2. Better quality). Appendix Figure S22. Subgroup analysis for one-month mortality. The selected studies were divided into the subgroups according to whether the risk estimate adjustment was performed in the selected studies. (1, without risk estimate adjustment; 2, with risk estimate adjustment). Appendix Figure S23. The bubble plot diagrams showed the meta-regression examining the heterogeneity in one-month mortality by different characteristics in the selected studies.

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