Endodontic Treatment Modifies Circulatory Inflammatory Mediator Levels: a Systematic Review
Notice bibliographique
Résumé
Objectives Apical periodontitis (AP) represents persistent inflammation within the periapical tissues mostly caused by a range of microorganisms of endodontic origin. Locally produced mediators and microbial virulence factors may enter the bloodstream and potentially sustain a persistent low-grade systemic inflammation, exerting an impact on the general health of the patient. This investigation aimed to systematically review and critically evaluate the evidence on reducing circulatory inflammatory mediators in patients with AP after successful endodontic nonsurgical and surgical treatment. Methods This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA) statement, and the protocol of the review was registered a priori with the PROSPERO. A literature search was conducted across the following electronic databases: Web of Science, Scopus, and PubMed from inception to March 2024, with no language restriction. The Gray literature was additionally searched to ensure study inclusivity. Observational studies with prospective or retrospective designs were included. Articles with duplicate or overlapping results, abstract-only papers, case reports, case series, animal studies, and reviews were excluded. All phases were completed by two independent researchers while disagreements were resolved by a third reviewer. The Newcastle–Ottawa Scale (NOS) was used to assess the quality of included studies. Results Sixteen studies were included in the final review following full-text evaluation. As the included studies reported different outcomes, the heterogeneity of data prevented a meta-analysis being undertaken. The included studies were published between 1990 and 2024, with a total of 957 participating individuals with an approximate age range of 18 to 70 years. Although different inflammatory mediators were assessed, most of the studies investigated the change in the serum levels of C-reactive protein before and after endodontic treatment. The overall quality of the evidence for the most included studies was ‘Fair’, while five studies were categorized as ‘Good’. Conclusions Based on ‘Fair’ and ‘Good’ quality of evidence it has been shown that successful endodontic treatment reduces the level of circulatory inflammatory mediators in patients with AP.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,003 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».