Feline oral neoplasms: a twenty-year retrospective survey and expression of amelogenin and ameloblastin in feline conventional (keratinizing) ameloblastoma and oral squamous cell carcinoma.
Notice bibliographique
Résumé
Feline oral neoplasms are underrepresented in scientific studies and reviews when compared with similar canine neoplasms. Oral neoplasms include those of the oral cavity, pharynx, gingiva, dental structures (odontogenic neoplasms), tongue, tonsils, and salivary glands. Oral neoplasms are common in cats representing 10-60% of all neoplasms in previous publications.\nIn Chapter 2 of the thesis, 569 surgical biopsies obtained from feline oral cavities submitted for routine diagnostic purposes between January 1998 and December 2019 were reviewed. Twenty-two different neoplasms were found. A majority of neoplasms were malignant (85%). The most frequently diagnosed were: squamous cell carcinoma (68.8%), peripheral odontogenic fibroma (5.3%), fibrosarcoma (4.4%), peripheral giant cell granuloma (3.5%), conventional (keratinizing) ameloblastoma (3.5%), and adenocarcinoma of the salivary gland (2.46%). The current study is the first one of its type conducted in Canada and the second one in North America. Compared to a previous North American study, fewer cases of fibrosarcoma (4.4% vs 12.9 %), and significantly more cases of conventional (keratinizing) ameloblastoma (3.5% vs 0.3%) were reported. Several neoplasms were identified in this study that were not seen in the previous study, these included: plasma cell neoplasm, hemangiosarcoma, and osteoma. \nOral squamous cell carcinoma (OSCC) and conventional ameloblastoma (CA) represent two epithelium-derived neoplasms that affect the oral cavity of cats and histologically may look similar. In Chapter 3, two immunohistochemical (IHC) markers, amelogenin and ameloblastin, were compared to determine usefulness in differentiation of the two neoplasms. The expression of amelogenin and ameloblastin has been previously established in the feline tooth bud and canine and human odontogenic tumors. The aim of this study was to characterize the amelogenin and ameloblastin expression profile of OSCC in comparison to CA. Samples from 15 OSCC and 15 CA cases were examined. Amelogenin expression was intranuclear in 15 OSCC cases, with all cases demonstrating high staining intensity. 14 of 15 CA cases demonstrated mild-moderate intranuclear staining intensity. Neither CA nor SCC expressed ameloblastin. Ki67 stained SCC samples had proliferation index 29.80% and CA had proliferation index 16.51%. \nThe difference in staining pattern and intensity of amelogenin and ameloblastin along with proliferation index of Ki76 in OSCC and CA did not help distinguish between the two neoplasia types.\nThe combined conclusions of the investigations are feline oral neoplasms are still an under researched area, ameloblastoma might be more common than previously thought, amelogenin and ameloblastin are not specifically expressed in odontogenic neoplasia, and Ki67 labeling index is not significantly different between OSCC and CA.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».