Towards Understanding the Relationship Between Hearing Loss and Cognition in Healthy Aging
Notice bibliographique
Résumé
Age-related hearing loss (ARHL) has been increasingly linked to cognitive decline, both directly and through structural brain changes. This study utilized data from the Aging Brain Cohort project at the University of South Carolina (ABC@UofSC) to investigate the relationships between hearing impairments, cognitive performance, and gray matter volume across key brain regions. Specifically, the study aimed to: (i) examine the mediating role of gray matter volume in the relationship between ARHL and cognitive impairments; (ii) investigate the role of regional brain age gap in mediating the relationship between ARHL and cognitive decline; and (iii) delineate the distinctive impact of ARHL on specific cognitive domains including memory, attention, and executive function. In a sample of 231 participants aged 20-79 years, cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA), focusing on general cognition, memory, attention, and executive function. Hearing performance was measured through pure-tone thresholds (PTT) and words-in-noise perception (WIN). Correlation analyses were employed to identify brain regions associated with hearing scores, and mediation analyses were conducted to determine whether these brain structures mediated the relationship between hearing impairment and cognitive performance, with a focus on specific cognitive domains such as memory, attention, and executive function. Findings highlighted the involvement of both auditory-specific regions, such as Heschl’s gyrus (HG) and the posterior superior temporal gyrus (pSTG), and non-auditory regions, including the cingulo-opercular (CO) network and domain-general (DG) areas, in mediating the link between hearing loss and cognitive impairment. Notably, the right hemisphere emerged as playing a more dominant role in the neural mechanisms linking hearing loss to cognition, supporting the right hemi-aging hypothesis, which posits greater age-related decline in the right hemisphere, particularly in sensory and cognitive functions. The findings revealed significant associations between hearing scores and general cognitive performance, with partial mediation through structural changes in both auditory and non-auditory regions. Furthermore, WIN scores were found to be more sensitive predictors of cognitive decline than PTT scores, particularly affecting executive control. The mediation analyses also indicated that structural changes in the hippocampus and frontal regions partially explained the link between hearing loss and cognitive deficits, with the right hemisphere playing a prominent role. The study concludes that ARHL contributes to cognitive decline, with structural changes in key brain regions, particularly in the right hemisphere, partially mediating this relationship. These findings provide important insights into the neural mechanisms underlying the hearing-cognition link and contribute to the growing evidence that hearing loss may be a potential modifiable risk factor for cognitive decline in aging populations.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».