Asbestos exposure and incidence of disease among a group of former chrysotile asbestos miners and millers from Baie Verte, NL, Canada
Notice bibliographique
Résumé
Asbestos is one of the most well-known and extensively studied occupational hazards. Over the past century, the health effects of asbestos exposure have been studied in thousands of books, journal articles, and media publications, from all over the world. Despite the vast amount of knowledge that exists about asbestos there continues to be controversy about the relative health risks associated with its different types, that is, serpentine (chrysotile) and amphibole asbestos fibres. The continued production and use of chrysotile asbestos in many countries around the world, as well as the ongoing exposure of millions of workers globally to asbestos, has kept it a subject of ongoing debate and concern. Although asbestos is a well-established cause of both malignant and non-malignant disease, a number of recent meta-analyses have sought to estimate the relative risk of diseases related to exposure to each of the different fibre types. The lack of epidemiological studies with good quality exposure assessments, particularly in the mining/milling industry, as well as the lack of retrospective exposure assessments for most cohorts, has led to an over-reliance on studies of a single population of chrysotile-only exposed cohorts: the Québec chrysotile miners/millers cohort. These studies, however, have been criticized as being heavily influenced by the asbestos industry. This thesis, which consists of an introductory chapter, three interrelated studies, and a concluding chapter, presents data on an under-studied cohort of chrysotile miners/millers from Baie Verte, Newfoundland and Labrador (NL), Canada. The first study will describe the development of a job exposure matrix (JEM) that was used to perform a retrospective exposure assessment for former workers of the mine/mill. The second study is an epidemiological assessment of a sub-group of the overall cohort of former employees who voluntarily joined the Baie Verte Miners Registry, an exposure/disease registry that was established to aid in the compensation process for former workers who have, or will, develop asbestos-related diseases. The third study outlines the process of enumerating the remainder of the cohort from historical union records (i.e., those who did not join the Baie Verte Miners Registry) and the epidemiological analysis of this group and of the two groups combined. Taken as a whole, this thesis demonstrates the good quality of the retrospective exposure assessment that has been conducted on this group of former asbestos workers and it supports the position that chrysotile asbestos is a cause of malignant mesothelioma. It also confirms the increased risk of asbestosis, as well as cancer of the lung, larynx, esophageal, and colorectum, in workers who were exposed to chrysotile asbestos. This cohort of chrysotile miners/millers is, therefore, a useful addition to the literature for estimating the relative potency of the different asbestos fibre types.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,002 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».