Hearing Loss is Associated with Widespread Alterations in Functional Connectivity in Adults with Mild Cognitive Impairment
Notice bibliographique
Résumé
Hearing-loss (HL) is prevalent in adults with mild cognitive impairment (MCI), a risk state for Alzheimer’s disease. Both MCI and HL are associated with alterations in brain connectivity. These connectivity alterations have been associated with cognitive impairment in both groups and progression to Alzheimer’s disease in individuals with MCI. This suggests that altered brain connectivity may be related to the cognitive decline and increased dementia risk in these two populations. Despite this, HL and cognitive impairment are rarely investigated together in the context of brain connectivity. Based on this, we characterized the relationship between two measures of hearing and brain connectivity in adults with MCI. All data are from the Comprehensive Assessment of Neurodegeneration and Dementia study of the Canadian Consortium on Neurodegeneration in Aging. Based on a pure-tone screening protocol participants were classified as having either normal hearing (NH, n=60, %female= 40%, age=74.5, education=15.19) or HL (n=35, %female=48%, age=70.07, education=16.5). Groups were matched on gender and did not differ in age/education/Montreal Cognitive Assessment scores. Speech reception-thresholds were used as a measure of supra-threshold hearing ability. Analyses tested whether default-mode network and Heschl’s gyrus connectivity differed as a function each hearing measure. In all analyses, age, education, reading acuity, and contrast sensitivity were included as covariates. In all analyses using speech-reception threshold as a variable, pure-tone HL was controlled for. Hearing loss was associated with widespread alterations in functional connectivity. Compared to participants with NH, those with pure-tone HL had decreased connectivity between the default-mode network and the bilateral caudate and right thalamus. Compared to individuals with NH, those with pure-tone HL had increased connectivity between right Heschl’s gyrus and the right insula, the right operculum, and within right Heschl’s gyrus itself. They also had decreased connectivity between right Heschl’s gyrus and three regions in the left frontal lobe. Poorer speech-reception threshold was also associated with decreased connectivity between right Heschl’s gyrus and three regions in the left frontal lobe. Finally, there was no relationship between either measure of hearing and the connectivity of left Heschl’s gyrus. These results show that in individuals with MCI HL is associated with altered functional connectivity in regions responsible for sensory and higher order cognitive processing. This suggests that the increased risk for cognitive decline and dementia seen in individuals with HL may be due to alterations in functional connectivity reducing the brains’ ability to compensate for aging and Alzheimer’s disease related brain pathology.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».