Advanced Control of a fed-batch reaction system to increase the yield in the polyhydroxyalkanoates production process
Notice bibliographique
Résumé
ABSTRACT: Plastics are one of the main products of the petrochemical industry, due to its wide variety of physical and chemical properties. However, the intensive use of plastics has created an important environmental problem, and therefore, many alternatives are currently explored for reducing it. The Polyhydroxyalkanoates (PHAs) are polymers from biological origins, which are an environmentally friendly option for replacing the use of petroleum based plastic materials in a wide number of applications [1], [2]. Currently, big companies in China, United States, Brazil and Canada are carrying out the production of PHAs at industrial level. However, in order to replace or at least to compete against the petroleum –based plastic materials, it is still needed to assure the technical and economic feasibility of the process. For this reason, it is important to develop strategies towards increasing the yield of the process. For this, advanced model-based control strategies must be applied instead of the classical control strategies, which have shown to be inefficient in many bioprocess applications [3], [4], [5] and [6]. Since 2012, the biotransformation research group at Universidad de Antioquia has conducted research projects towards finding a technical and economical feasible alternative for producing PHAs using Colombian agricultural wastes. Preliminary results obtained at bioreactor scale have shown to be promising assuring the technical feasibility of the production process. However, in order to increase the productivity of the process for assuring its economic feasibility, optimization and control tools are proposed to be used in this master thesis. In this work, the optimizing control of the PHAs fed-batch process is carried out by formulating and solving a dynamic optimization problem for maximizing the process productivity. The optimization problem is subject to constraints on the feed flow rates, the final volume and the maximum concentrations reached on the substrate and nitrogen source, in order to avoid inhibition. Furthermore, the number average molecular weight distribution (Mn) is predicted using state estimation strategy and is used as constraint in order to fulfill desired end-product specifications. By solving the problem stated, it was possible to find the optimal values for the substrate and the nitrogen source feed concentrations, as well as their optimal feeding profiles that maximize the process productivity. Solution of the dynamic optimization problem was carried out by the control vector parameterization approach. Different kinds of parameterization for the control vector were tested in order to compare their advantages and disadvantages. Results of the dynamic optimization problem have shown that sinusoidal type control profiles lead to higher productivity values (i.e. in comparison to step-type or constant feeding policies), while fulfilling the constraints, being remarkable that the number average molecular weight was kept around 4.05x105 g/mol and the productivity of the final amount of polymer over 138.44 g or 0.62 g/Lh for a 32 h fermentation and a final volume of 7 L. Finally, it was shown that the optimizing control strategy coupled to the prediction of Mn is an interesting and applicable alternative that could help to improve the PHAs productivity at industrial scale. Further work will be directed towards applying the mentioned strategy experimentally at pilot plant scale.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».