Effect of consuming dairy fats on circulating fatty acid profile and metabolism
Notice bibliographique
Résumé
Increased interest has focused on associations between dietary fatty acids and cardiovascular disease (CVD). Current findings delineating effects of consuming saturated fatty acids (SFA) from dairy on CVD risk remain controversial. The objective of this thesis was to investigate the effects of consuming two types of dairy fat, namely those from cheese and butter on, human plasma and RBC fatty acid profiles, compared with monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA) and carbohydrate (CHO). A secondary objective was to investigate the association between consuming these dietary fatty acids and endogenous de novo fatty acid synthesis. A randomized, full-feeding, crossover, single-blinded clinical trial was conducted at the Institute of Nutrition and Functional Foods (INAF), Laval University and Richardson Centre for Functional Foods and Nutraceuticals (RCFFN), the University of Manitoba. A total of 92 women and men with abdominal obesity and relative low high density lipoprotein cholesterol (HDL-C) levels were randomized into a series of 5 treatments. The duration of each treatment was 4 weeks and separated by at least 4 weeks washout period. For plasma fatty acid profile, total plasma SFA after cheese treatment was found to be higher (P<0.05) than after MUFA, PUFA and CHO treatments, whereas total plasma SFA after butter treatment was only found to be higher (P<0.05) than after MUFA and PUFA treatments. Total plasma MUFA after MUFA treatment was higher (P<0.05) than after all other treatments, and total plasma PUFA after PUFA treatment was higher (P<0.05) than after all other treatments. Unlike plasma fatty acid profile, RBC total SFA after two dairy treatments were not higher than after CHO and PUFA treatments. Consistent with the plasma fatty acid profile, RBC total MUFA after MUFA treatment were found to be higher (P<0.05) than after all other treatments. Similarly, RBC total PUFA after PUFA treatment were higher (P<0.05) than after all other treatments. We did not detect any differences in de novo palmitic acid synthesis across all treatments in the present study. However, we did see a positive correlation between de novo palmitic acid synthesis and body fat mass. In summary, present results suggest that consuming dairy fats, from cheese or butter, can significantly modulate plasma fatty acids in a manner that increases plasma total SFA, including myristic acid (C14:0), pentadecanoic acid (C15:0), palmitic acid (C16:0) and heptadecanoic acid (C17:0). However, the effect of consuming dairy fats on RBC fatty acid profile is relatively minor. Additionally, the de novo fatty acid synthesis data suggests that the quality of dietary fatty acids does not associate with human endogenous fatty acid synthesis; unlike body fat mass.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».