Notice bibliographique
Résumé
This aim of this systematic review and meta-analysis is to obtain best estimates of the effect of outpatient HCQ intervention for COVID-19 with hospitalization prevention as the main outcome. Methods This study will be conducts with adherence to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines and will be prospectively registered on PROSPERO. Searches A comprehensive search of the following databases was comprehensively searched on November 29, 2020 with the aid of a librarian at McMaster University: MEDLINE, EMBASE, medRxiv. Search strategy MEDLINE and EMBASE 1. Covid-19.ti,ab. 2. 2019-nCoV.ti,ab. 3. SARS-CoV-2.ti,ab. 4. 2019 novel coronavirus.ti,ab. 5. Wuhan coronavirus.ti,ab. 6. New coronavirus.ti,ab. 7. Coronavirus.ti,ab. 8. Hydroxychloroquine.ti,ab. 9. 1 or 2 or 3 or 4 or 5 or 6 or 7 10. 8 and 9 11. limit 10 to randomized controlled trial MEDRxiv “Hydroxychloroquine AND (covid-19 OR 2019-nCoV OR SARS-CoV-2 OR 2019 novel coronavirus OR Coronavirus) AND randomized" Inclusion/exclusion criteria Inclusion criteria Any randomized controlled trials that examine HCQ intervention for COVID-19 outpatient prophylaxis, with hospitalization as an outcome Exclusion criteria Full text could not be found Conditions or domain being studied COVID-19 Participants/population Outpatient with a diagnosis of COVID-19. Interventions, exposures HCQ or chloroquine Comparators Placebo or control Main outcomes The primary outcome will be hospitalization rates. Additional outcomes Duration of hospitalization Deterioration on 7-point scale (if reported) Mortality Data synthesis Eligibility, screening (title/abstract and full-text), and extraction will be carried out by two independent reviewers and collected through Covidence software for systematic reviews (Veritas Health Innovation Ltd). Data extracted will include authors, country study was conducted in, journal, date of publication, location of study, RCT design, number of patients total and in each group, demographics, comorbidities, disease severity at baseline, patient status, intervention timing in relation to onset of symptoms and in relation to timing of diagnosis, dosage, number (%) of hospitalizations in each group, hazard ratio (95% CI), and 7 point scale if available, duration of hospitalization. Any disagreement across screening and data collection will be resolved through joint discussion between the two reviewers and a third reviewer. Studies excluded at the full-text stage will have a corresponding reason for exclusion. A PRISMA flow chart will be created in order to document the extraction process. Risk of Bias (Quality Assessment) Cochrane risk of bias Statistical analysis The meta-analysis will be conducted using Revman 5. All descriptive statistical analyses will be performed using GraphPad Prism (GraphPad Software Inc., San Diego, Cali.) or MS Excel (Microsoft, Redmond, Wash) and summarized in tables and graphs. Analysis of subgroups or subsets We will note open vs. blinded trials and potentially analyze and conduct a sub meta-analysis if data allows Contact details Allen Li Allen.li@uottawa.ca Organizational affiliation of the review McMaster University, Faculty of Health Sciences McMaster University, Michael D. Degroote School of Medicine University of Ottawa, Faculty of Medicine McMaster University, Department of Medicine Review team members and their organized affiliations Ms. Sarah Yang, McMaster University, Faculty of Health Sciences Ms. Sofia Ivanisevic, McMaster University, Faculty of Health Sciences Mr. Adrian Salopek, McMaster University, Faculty of Health Sciences Mr. Allen Li, University of Ottawa, Faculty of Medicine Mr. Ali Eshaghpour, McMaster University, Michael D. DeGroote School of Medicine, Dr. John Eikelboom, McMaster University, Department of Medicine Dr. Mark Crowther, McMaster University, Department of Medicine References 1. Coronavirus disease (COVID-2019) situation reports. Geneva: World Health Organization, 2020 (https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/). 2. Rolain J-M, Colson P, Raoult D. Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century. Int J Antimicrob Agents 2007;30:297-308. 3. Hernandez AV, Roman YM, Pasupuleti V, Barboza JJ, White CM. Hydroxychloroquine or chloroquine for treatment or prophylaxis of COVID-19: a living systematic review. Ann Intern Med 2020 May 27 (Epub ahead of print).
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,052 | 0,108 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,002 |
| Méta-épidémiologie (sens large) | 0,005 | 0,008 |
| Bibliométrie | 0,004 | 0,005 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,005 | 0,006 |
| Science ouverte | 0,005 | 0,004 |
| Intégrité de la recherche | 0,006 | 0,005 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,366 | 0,080 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».