Association Between Sarcopenia Susceptibility and Cesarean Section: A Study Based on National Health and Nutrition Examination Survey (NHANES) and Mendelian Randomization
Notice bibliographique
Résumé
Feng Tian,1,2,&ast; Huiying Pan,3,4,&ast; Qi Wu,2 Dapeng Jiang2 1Department of Pediatric Surgery, Suzhou Wujiang District Children’s Hospital, Suzhou, Jiangsu Province, People’s Republic of China; 2Department of Oncology (Ward 2), Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 4Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Dapeng Jiang, Department of Oncology (Ward 2), Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Email jdp509@163.comObjective: To investigate the relationship between sarcopenia susceptibility and cesarean section (CS) and to assess causality using Mendelian randomization (MR).Methods: Data from 1,316 individuals aged from 20– 59 in National Health and Nutrition Examination Survey (NHANES) 2013– 2016 were included in the study. The association between sarcopenia and CS was investigated by adjusting for confounders using multivariable linear and logistic regression analysis. Two-sample bidirectional MR was employed to evaluate causal relationships. Genetic data associated with CS (n=462,933) and appendicular lean mass (ALM, n=450,243) were sourced from the largest genome-wide association studies (GWAS). The primary analytical method used was inverse variance-weighted (IVW).Results: Based on the cross-sectional study, the number of CS was positively correlated with sarcopenia across all adjusted models, whereas no such association was observed with vaginal delivery (VD). Subgroup analyses indicated that these associations were primarily evident among premenopausal women. IVW-MR analysis revealed a significant association between sarcopenia and CS (OR=0.989, 95% CI: 0.984 to 0.994, P< 0.001), but there was no statistically causal link in reverse (OR=2.100, 95% CI: 0.012 to 364.040, P=0.779).Conclusion: A significant positive correlation and potential causal relationship between sarcopenia susceptibility and CS were identified, which highlighted the need for increased attention to sarcopenia in women with a history or high likelihood of CS, including but not limited to muscle health assessments during prepartum and postpartum periods, along with necessary muscle-strengthening interventions. Keywords: sarcopenia, cesarean section, menopause, gestational diabetes mellitus (GDM), NHANES
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».