CANFLAX: can flaxseed “milk” prevent broken hearts in women with breast cancer?
Notice bibliographique
Résumé
Background: Cardiovascular disease and cancer are major public health concerns worldwide. Despite the beneficial effects of the anthracycline based anti-cancer agent Doxorubicin (DOX) in treating women with breast cancer, cardiotoxicity is a major challenge. Although recent basic science studies have demonstrated the cardioprotective role of flaxseed (FLX) in the prevention of DOX mediated cardiotoxicity, little is known about the effects of this nutraceutical in the clinical setting. The aim of the “Can flaxseed “milk” prevent broken hearts in women with breast cancer?” (CANFLAX) study is to investigate whether consumption of FLX “milk” can prevent heart failure in women with breast cancer treated with anthracyclines. Methods: In this double-blind prospective randomized controlled clinical trial, prior to initiation of DOX-based chemotherapy, women with breast cancer were randomized to either placebo oat fiber “milk” or FLX “milk” for a total of 4 months. Baseline demographic data, echocardiography, and blood work were measured at baseline, 4-months, 6-months and 12-months post-intervention. Baseline demographic data was collected using CancerCare Manitoba’s medical record database (ARIA) MedOncology Manager. Serial transthoracic echocardiography (TTE) was conducted to assess cardiovascular systolic and diastolic function, including strain parameters. Results: A total of 18 women with early-stage breast cancer (EBC) have been enrolled between September 2021 to December 2022 in the CANFLAX study. Out of the 18 participants, 15 women (mean age 4710 years) with average body mass index (BMI) of 295.2 kg/m2 have completed both the baseline and 4 month follow-up. Out of this cohort of 15 women, a total of 6 were randomized to group A and 9 were randomized to group B; the identity of the 2 study products is double-blinded. The prevalence of underlying cardiovascular risk factors was low in both groups. In total, 2 (13%) participants had hypertension, 1 (6%) participant had hyperlipidemia, diabetes, and past smoking history, and 5 (33%) participants had a family history of premature coronary artery disease (CAD). The overall “milk” adherence was rate was approximately 70% during the 16 week “milk” intake period. There were no significant differences between the two groups in the measured cardiovascular morphological or functional parameters. The baseline left ventricular ejection fraction (LVEF) values were 683% and 694%, for groups A and B, respectively. At 4 months follow up, mean LVEF was 69±3% and 70±2% in group-A and group-B, respectively (p = NS). Additionally, at baseline, the mean global longitudinal strain (GLS) was -18.2±0.3% in group-A and -18.4±0.3% in group B (p=NS). At 4 months follow up, the GLS was lower in Group A at -14.9±0.2% in comparison to a GLS of -18.1±0.2% for Group B (p<0.05). Conclusion: The findings of the ongoing CANFLAX study highlight the feasibility of consuming either oat fibre “milk” or flax “milk” in women treated with anthracyclines for breast cancer. Whether the prophylactic administration of FLX “milk” is cardioprotective in the setting of anthracycline-mediated cardiotoxicity in the breast cancer setting remains to be determined.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,006 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».