The link between perinatal depression and DNA methylation of the oxytocin receptor gene: a study of mothers and their children
Notice bibliographique
Résumé
Background: There is mounting evidence to suggest that exposure to stress during critical periods of development may increase one's susceptibility to disease risk, including depression. Perinatal depression (PD) may not only be associated with adverse outcomes among the mothers experiencing it, but also for the children exposed to PD, via epigenetic programming. We sought to investigate how PD may be associated with certain epigenetic profiles among mother and child dyads. Specifically, we focused on the oxytocin receptor (OXTR) gene due to oxytocin's role in maternal behavior and stress regulation. It is hypothesized that increased OXTR methylation will be observed for those mothers who experience PD and among those children exposed to PD. Methods: Using longitudinal data from a cohort of mothers and their infants, we collected information about the mothers' depressive symptomology across 5 time points (twice during pregnancy and three times during the postpartum period). Depressive symptomology was assessed using the Edinburgh Postnatal Depression Scale (EPDS) and four groups were established based on EPDS cut-off scores: no PD, prenatal or postpartum depression only and persistent PD (depression both prenatally and postpartum). DNA methylation was assessed using saliva obtained from both mother and child at the last time point – 2.9 years postpartum, for which the OXTR gene was interrogated for methylation patterns. Results: Those mothers with persistent PD had significantly higher OXTR methylation overall compared to the other groups. Specifically, 9 of the 22 CpG sites interrogated were significantly higher for the persistent PD group. However, average OXTR methylation among those children who were exposed to their mothers' persistent PD were not significantly different when compared to the other groups, with none of the 22 sites investigated within the exon 3 region showing significantly different methylation patterns. Discussion: For mothers, only persistent PD was associated with significantly higher OXTR methylation suggesting that more transient episodes of depression may not impact the epigenome to the same degree. The children's methylation profiles were not consistently associated with their mothers' depression. Given the link found between persistent PD and OXTR methylation among mothers, the combined psychological and epigenetic risk may have implications for the oxytocin system as well as compromise maternal behavior which may result in negative outcomes for the developing child.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».