Fitness & major histocompatibility complex diversity of two bottlenose dolphin populations
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Notice bibliographique
Résumé
Low genetic diversity diminishes the potential to adapt to change and thus reduces individual fitness as well as population viability. Therefore, it is crucial to identify genetic variation that affects fitness and population viability. Until recently, the search for the genetic basis of fitness variation, and the related field of conservation genetics, have mostly relied on neutral genetic markers, such as mitochondrial DNA and microsatellites. However, ecological and evolutionary processes relevant to fitness can only be inferred by non-neutral genes, such as those of the major histocompatibility complex (MHC). \nIn this thesis I examined the interplay between demographic parameters, fitness and MHC genetic diversity of two West Australian populations of bottlenose dolphins (Tursiops cf aduncus): a large population (N ≈ 3000), in Shark Bay (SB) and a much smaller population (N ≈ 250) off Bunbury (BB). With collaborators, I assessed demographic parameters, characterized MHC variation, and investigated the relationship between fitness and MHC diversity. \nIn chapter 2, our demographic analysis showed that the SB population, which is comparatively unimpacted by human activity, was much larger and displayed greater reproductive output than the urban BB population. Reproductive rates of the SB population showed large temporal fluctuations. In chapter 3, using a combination of Sanger and next-generation Illumina MiSeq sequencing, we identified a large variety of MHC sequence variants. We also classified MHC supertypes, variants which encode particular antigen binding sites with differing physiochemical properties. These MHC supertypes may serve as an improved marker for biologically relevant genetic variation. Transcription of some of the MHC sequence variants was confirmed in both populations. Chapter 4 shows that the larger SB population displayed greater MHC diversity—nucleotide diversity and a novel measure of ‘supertype diversity’—than the BB population. The SB population is, therefore, potentially more robust to environmental changes. In chapter 5 we report a strong association between MHC diversity and individual fitness: For example, offspring produced by mothers who were heterozygous for one MHC locus were much more likely to survive to weaning age, than offspring of homozygous mothers. Thus the MHC variation identified in this thesis provides a reliable basis for further studies on the relationship between genetic diversity, fitness and population biology.
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Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,010 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle