Depression in patients under investigation for occupational asthma: clinical, immune, behavioral, and employment aspects
Notice bibliographique
Résumé
Asthma and depression are highly prevalent and often co-occurring conditions with substantial personal, social, and economic impact worldwide. Little is known about psychological factors in occupational asthma (OA), a type of asthma caused by exposure to workplace substances. Individuals under medical investigation for OA face distressing respiratory symptoms and uncertain occupational implications. Although preliminary evidence indicates a high rate of depression among patients under investigation for OA (UIOA), the impact of depression on patient health and well-being is unclear. The current dissertation examines whether major depressive disorder (MDD) and depressive symptomatology contribute to the burden of illness in people UIOA. Two original research studies were conducted, considering multiple clinical and functional aspects: respiratory symptom burden, physiological indices including lung function and immune alterations, health behaviors, and employment. Study 1 examined the cross-sectional relationships between depression and respiratory symptom burden in a sample of 220 patients currently being evaluated for OA. Participants underwent a socio-demographic, medical, and psychiatric interview, and completed a battery of questionnaires on the day of their asthma clinic visit. Hospital medical chart reviews were conducted to obtain physiological, diagnostic, and prescription information. Results showed that MDD and higher depressive symptoms were associated with worse control of respiratory symptoms, worse quality of life related to respiratory symptoms, and an increased percentage of eosinophils in sputum. Depressive symptoms were also associated with an increased percentage of neutrophils and a decreased percentage of lymphocytes in blood. MDD was associated with smoking.Extending this work, Study 2 examined longitudinal associations between baseline MDD and depressive symptoms with future respiratory and occupational outcomes in 131 patients who were re-contacted approximately 18 months after their initial evaluation for OA in Study 1. Participants again underwent a socio-demographic, medical, and psychiatric interview, and completed a battery of questionnaires. Results indicated that patients with MDD and those who report more depressive symptoms during evaluation for OA tend to have more poorly controlled respiratory symptoms at follow-up relative to other patients. Over time, measures of baseline depression were also associated with deteriorating quality of life related to respiratory symptoms, failure to return to work, and increasing on-the-job limitations. Overall, findings suggest that MDD and depressive symptoms play a significant role in the health and well-being of people UIOA. The present research adds to the growing chronic illness literature demonstrating the adverse effects of depression on health and employment. Implications and directions for future research are discussed.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».