Endovascular Treatment in Stroke Patients of Working Age: A Multicenter Observational Study of Real-World Outcomes
Pourquoi ce travail est dans la base
Une base qui oublie comment elle a trouvé un travail ne peut pas être vérifiée. Voici les voies qui ont admis celui-ci.
Notice bibliographique
Résumé
Yongting Zhou,1 Mohammad Mofatteh,2 Zijie Zheng,3 Feng Liu,4 Sijie Zhou,5 Jicai Ma,6 Zile Yan,7 Yuzheng Lai,8 Weijiang Li,1 Weiying Chen,1 Mohamad Abdalkader,9 Robert W Regenhardt,10 Xiangmin Liu1 1Department of Neurology, Huadu District People’s Hospital of Guangzhou, Guangzhou, People’s Republic of China; 2School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, UK; 3School of Automation Science and Engineering, South China University of Technology, Guangzhou, People’s Republic of China; 4Department of Internal Medicine, Huadu District People’s Hospital of Guangzhou, Guangzhou, People’s Republic of China; 5Department of Surgery of Cerebrovascular Diseases, First People’s Hospital of Foshan, Foshan, Guangdong Province, People’s Republic of China; 6Department of Neurology, The Affiliated Yuebei People’s Hospital of Shantou University Medical College, Shaoguan, People’s Republic of China; 7Department of Neurology and Advanced National Stroke Center, Foshan Sanshui District People’s Hospital, Foshan, Guangdong Province, People’s Republic of China; 8Department of Neurology, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine (Nanhai District Hospital of Traditional Chinese Medicine of Foshan City), Foshan, Guangdong Province, People’s Republic of China; 9Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; 10Department of Neurology, Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USACorrespondence: Xiangmin Liu, Department of Neurology, Huadu District People’s Hospital of Guangzhou, Guangzhou, People’s Republic of China, Email 13560494238@163.comPurpose: The prevalence of acute ischemic stroke (AIS) is increasing among people of working age, posing socioeconomic and healthcare challenges. Inability to return to work can have significant negative consequences and contribute to the economic burden of stroke. Endovascular treatment (EVT) has been established as the standard of care for large vessel occlusion AIS patients. In this study, we aimed to identify factors predicting favorable outcome among working age AIS patients undergoing EVT.Patients and Methods: We analyzed data from 309 patients from five comprehensive stroke centers between 2019 and 2023. All patients were working age (18< 59) with symptoms onset of within 24 hours. Modified thrombolysis in cerebral infarction (mTICI) score of 2b-3 was considered as successful recanalization. We used 3-months mRS post-EVT to evaluate the outcome; mRS of 0– 2 was defined as favorable outcome, whereas mRS of 3– 6 was considered unfavorable outcome.Results: The unfavorable outcome group consisted of 150 patients, and 159 patients were in the favorable outcome group. More people in the unfavorable outcome group had diabetes (29.33% vs 15.72%, p=0.004) and hypertension (61.33% vs 40.88, p< 0.001). A multivariable regression analysis demonstrated that several factors, including successful recanalization (odds ratio (OR) 5.298, 95% confidence interval (CI) 1.735– 16.174, p=0.003), pre-EVT NIHSS (OR 0.892, 95% CI 0.852– 0.934, p=0.000), baseline Alberta stroke program early CT score (ASPECTS) (OR 1.609, 95% CI 1.274– 2.032, p=0.000), hypertension (OR 0.477, 95% CI 0.270– 0.845, p=0.011), diabetes mellitus (OR 0.413, 95% CI 0.208– 0.820, p=0.011), and symptomatic intracerebral hemorrhage (sICH) (OR 0.045, 95% CI 0.006– 0.359, p=0.003) can predict the outcome of patients undergoing EVT.Conclusion: Favorable outcome of working age patients with AIS undergoing EVT can be predicted using multiple factors, including hypertension, diabetes mellitus, successful recanalization, pre-EVT NIHSS, baseline ASPECTS, and sICH.Keywords: acute ischemic stroke, endovascular treatment, thrombectomy, China, working age, patient outcome
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle