The Impact of Glucose on Cognition in Neurodegenerative Disease
Notice bibliographique
Résumé
Glucose dysregulation has been associated with poorer cognitive functioning in healthy adults with and without diabetes, as well as in individuals with neurodegenerative disease. In addition to cognitive changes, hyperglycemia has also been associated with brain atrophy, and this is especially true for those with the apolipoprotein E (ApoE) ε4 genotype. However, most of these studies rely on cognitive screening measures of dementia with vast variations in how cognition is assessed. This precludes the ability to make conclusive inferences from findings that have not assessed cognition consistently nor comprehensively. \n\nIn the present study, the effects of glucose on cognition were examined across healthy aging, and two neurodegenerative diseases, namely Alzheimer’s (AD) and Parkinson’s disease (PD), with the goal of assessing cognition in a detailed and standardized manner across cohorts. Data from the Ontario Neurodegenerative Disease Research Initiative was used to assess three cohorts of healthy adults and individuals with AD and PD. The primary interest was to analyze the effects of elevated glucose levels on cognition after controlling for related covariates of triglycerides, hypertension, and smoking. Secondary analyses examined the roles of genetics, and brain volume with glucose. \n\nHigher glucose levels were differentially related to disease status and cognitive abilities after controlling for the effects of triglycerides, hypertension, and smoking. In healthy adults and those with PD, glucose levels were associated with poorer cognition, but not in those with AD. Among healthy adults, this effect was due to worse language and visuospatial abilities whereas widespread cognitive changes over domain-specific impairment was observed in those with PD. In AD, glucose levels were not associated with cognition. No significant interaction emerged between ApoE-ε4 carriers and glucose in neurodegenerative disease. An interaction between lower brain volume and poorer cognition was observed among those with higher glucose levels in the healthy adult group but not in the PD or AD groups.\n\nHyperglycemia appears to have a different relationship in those with and without neurodegenerative disease. In healthy adults, it may be possible that even glucose levels within the normal range may be exerting deleterious effects that manifest clinically, affecting both cognition and brain volume. In neurodegenerative disease, more research is needed to understand the complex relationship between hyperglycemia and specific disease pathology. With the consistent increase in both diabetes and dementia, close monitoring of glucose levels may be a potential modifiable risk factor that contributes to optimal brain health to reduce the risk of a dementia diagnosis.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».