Histiocytic sarcoma as a breed specific disease in the Flat-coated retriever
Notice bibliographique
Résumé
The Flat-coated retriever is a small breed of dogs as far as numbers are concerned, and developed in England in the mid 1800s when the need for a retrieving breed became evident. It is believed to be a mix of several other breeds, with the St. Johns dog from Newfoundland as an important participator. After being very popular at the turn of the century, its popularity declined in the 1920s, and this combined with very little breeding during World War II resulted in a very small number of flats after the war. In 1947 only 75 dogs were registered in England. To save the breed all dogs available were used in breeding, no matter age or faults. Nowadays there are populations of FCRs spread throughout Europe and USA, but it remains a relatively small breed. A problem with tumour diseases (cancer) is recognized in the breed “everywhere”, and researchers have taken an interest in this in several countries. The theory is that this is a genetic disease, and the hunt for the gene(s) responsible has been ongoing for a number of years already. There is especially one type of soft tissue sarcoma that has been dominating among the malignant tumours in this breed, and over the years it has been given several names: undifferentiated soft tissue sarcoma, malignant fibrous histiocytoma, malignant histiocytosis, and histiocytic sarcoma, to mention a few. In recent years the scientists seem to have landed on the term histiocytic sarcoma (HS) as a common name for all these tumours. England, and the University of Cambridge, is the place where the research has been going on the longest, and this is also the place that seems to have achieved most results with their research. However, research is also ongoing in Sweden and the US to find the genes responsible and from there try and find out how to best handle the disease. In Sweden the research is more aimed at cancer in general than HS in particular. For the future we can hope hope that the research will succeed, and that genetic testing of dogs can help in the eradication of the disease, as well as in the therapy of it.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».