Metacognition in individuals with a lifetime history of anorexia nervosa: a voxel based morphometrystudy.
Notice bibliographique
Résumé
Objective: The aim of the current study was to provide a preliminary investigation of metacognition (MC) and global and regional cerebral volume in women with a lifetime history of Anorexia Nervosa (AN) compared to healthy controls (HC). In particular, we aimed to explore whether (1) MC was still affected in recovered AN patients (rec-AN) compared to HC and (2) prefrontal areas sustaining MC were morphometrically different in rec-AN compared to HC, using magnetic resonance imaging (MRI). Method: Nine adult drug-free rec-AN females (age: M=23.22; SD=+5.91) and nine adult HC (age: M=23.33; SD=+2.67) underwent the psychometric assessment consisting of the Thought Control Questionnaire (TCQ), the Metacognition Questionnaire (MCQ), the Toronto Alexithymia Scale-20 (TAS-20) and high resolution T1-weighted voxel based morphometric (VBM) MRI (224 contiguous slices, voxel size = 0.7×0.7×0.7, FOV=320×320, TR=20ms, TE=4.89ms, band = 130Hz/Px), using a 1.5 Tesla Siemens Magneton Avanto scanner. We used Voxel-Based Morphometry (VBM) to characterize brain differences in gray matter volume between the groups. Local grey matter volume (GMV) differences between the two groups were detected using a Region of Interest (ROI) analysis and a Whole Brain Analysis to strengthen and widen the ROI's results (with p<0.001). Based on the evidence regarding the neural basis of metacognition [1], masks were created around twelve areas, mainly located in the frontal lobes. Mann–Whitney test was performed to compare TCQ, MCQ and TAS-20 scores between rec-AN and HC, with α set at < 0.05. Results: The analyses revealed that rec-AN and HC did not differ for both metacognitive abilities, alexithymic traits and global GM volumes. The Region of Interest (ROI) analysis showed reduced GMVs in the right Superior Frontal Gyrus (SFG) and increased GMVs in the Temporo-Parietal Junction (TPJ) and Inferior Frontal Gyrus (IFG) in rec-AN compared to HC. Besides, the Whole Brain Analysis (WBA) found that rec-AN, compared to HC, showed reduced GMVs in the Left Superior Parietal Lobule (SPL), the Left Inferior Frontal Gyrus (IFG), the Right Inferior Occipital Gyrus (IOG), the Left Fusiform Gyrus (FG) and the cerebellum's culmen but not in the DLPFC. Conclusion: The GMV reduction seems to be aspecifically distributed in different brain areas, as found in other VBM studies which investigated adult acute and weight-restored AN patients [2,3]. Several lines of evidence sustain that frontal, parietal, temporal, occipital and cerebellar regions are involved in body shape perception, cognitive and emotional processing, which are often impaired in AN [3]. However, there was no GM decrease in brain areas specifically supporting metacognitive functioning [1], which was not compromised in rec-AN. These findings suggest that clinical recovery (i.e. achievement of adequate body weight and remission of Eating Disorder psychopathology) may accompany the restoration of neurobiological underpinnings of ‘thinking about thinking’ processes, and that MC impairment may not represent a stable marker of AN. Differences in regional GM volume may be linked to the past starvation, but whether they are state or trait is unclear. These discrete brain volume differences provide candidate brain regions for further structural and functional study in people with Eating Disorders.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».