Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Patients with Post-Stroke Comorbid Cognitive Impairment and Depression
Notice bibliographique
Résumé
ObjectiveTo observe the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) on patients with post-stroke comorbid cognitive impairment and depression (PSCCID).MethodsA total of 30 patients with PSCCID were treated in the department of rehabilitation medicine of Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital from January 2018 to December 2020 were randomly divided into control group and observation group, with 15 cases in each group. The control group received routine medication treatment and routine rehabilitation, including exercise therapy (40 minutes a time, once a day, five days a week), occupational therapy (30 minutes a time, once a day, five days a week), and cognitive training (30 minutes a time, once a day, five days a week), for four weeks. The observation group received high-frequency rTMS treatment (stimulation of the left dorsolateral prefrontal cortex, 10 Hz, 100% resting motion threshold, 20 minutes a time, once a day, five days a week) for four weeks, in addition to the treatment received by the control group. Before and after treatment, the Montreal cognitive assessment (MoCA) and the mini-mental state examination (MMSE) scores were used to assess cognitive function. The 17-item Hamilton depression rating scale (HAMD-17) was used to assess depression. The 3.0T magnetic resonance imaging system was used to scan the patient's brain, and voxel-based morphological analysis was used to analyze the changes of gray matter density in local brain areas.ResultsCompared with those before treatment, the MMSE and MoCA scores were higher and the HAMD-17 score was lower in both groups after treatment, and the differences were statistically significant (<italic>P</italic><0.05). Compared with the control group, the MMSE and MoCA scores were higher in the observation group after treatment, and the HAMD-17 score were lower, and the differences were statistically significant (<italic>P</italic><0.05). Compared with the control group, gray matter density in the left head and face regions of precentral gyrus, and the left caudal area of middle temporal gyrus of the observation group were higher, while gray matter density in the left medioventral occipital cortex and right middle frontal gyrus were lower, and the difference was statistically significant (<italic>P</italic><0.05).ConclusionHigh-frequency rTMS can improve cognitive function and depression of patients with PSCCID, and the mechanism may be related to the increase of the gray matter density in local brain regions.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».