Polymorphysm and connection with risk factors of some genes of predisposition to cardiovascular diseases in ethnic groups in Siberia (molecular-epidemiological and evolution-genetic aspects)
Notice bibliographique
Résumé
Analysis of mitochondrial DNA polymorphism in different ethnic groups in Euro-Asia testify to risk the possibility of their formation from the same ancient human population in Control and Middle Asia with the initial divergence of western and eastern poles contrast in anthropology and genetics and with the following radial divergence with modern ethnic groups. The closest to the ancestral state of western protopopulation is gene pool of suburban ethnic groups in Europe and West Siberia. The important role in forming peculiarities of nuclear genes polymorphism belonged to its adaptive meaning. The levels of ApoE and ACE genes polymorphism in European Siberian population is close to that registered in West Europe. The frequency of E2, E3 and E4 alleles of ApoE gene were 0.057; 0.823 and 0.120 accordingly. The frequency of I and D alleles of ApoE gene were 0.477 and 0.523 accordingly. In the native population of Chukotka in case with ApoE gene only E3 and E4 alleles and frequency 0.826 and 0.174 were revealed. Frequency of I and D alleles of ACE gene were 0.6890 and 0.320. According to polymorphism level of ApoE and ACE genes the natives of Chukotka differ from European ethnic groups and are close to the native population of the artic region of North America. ACE gene polymorphism in European Siberian population is not associated with AP levels. In Chukotka natives significant association of ACE gene polymorphism with pulse AP was revealed. The frequency of D/D genotype of Alu-insertion polymorphism of APF gene is reliably increasing after 50 years of age in male European population in Novosibirsk. In the age group 45-64 the decrease of the frequency of homo- and heterozygous genotypes of ACE gene with insertion of Alu-element is observed, maybe, due to higher mortality level among their carrier. In the European male population in West Siberia ApoE gene polymorphism is reliably associated with variability of cholesterol and triglyceride levels, mainly at the expense of E2 allele. The increase of their levels in the raw of E2/2, 2/3, 2/4 genotypes was found. In Chukotka natives ApoE polymorphism is connected with variability of cholesterol levels in women. It was revealed that in the population of arctic mongoloids in Chukotka and North America specific alleles variant of ApoB 3405Glu is wide spread. Its frequency is 0.090, 0.180 and 0.175 in chukchies and Canadian Eskimos accordingly. The presence of thus allele in the genotype leady to the increase of cholesterol level in women independently and in interaction with ApoE polymorphism. There are some difference in genotypes and alleles frequency by this polymorphism in sex groups. The new c-fms gene polymorphism was found spread both in European and mongoloids populations of North Asia. The frequency of more rare allele is 0.231 in male European population in Novosibirsk and 0.236 in natives of Chukotka. This polymorphism is characterized by differences in genotypes frequency between age groups and is significantly associated with variability of Ch-HDL level in Novosibirsk men.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».