Comparison of catheter and CT biventricular pressure-volume analysis during pressure overload
Notice bibliographique
Résumé
Background: Admittance catheter-derived pressure–volume (PV) analysis offers the ability to assess dynamic changes in ventricular performance. The present study was designed to evaluate the feasibility and accuracy of biventricular PV analysis by comparing admittance catheter-derived measurements of left (LV) and right ventricular (RV) volumes with data obtained from simultaneous contrast-enhanced cardiac multi-detector computed tomography (MDCT) before, during, and after transient pressure overload (TPO) in swine. Load-independent parameters of LV and RV systolic function were also assessed to determine whether each ventricle exhibits a similar susceptibility to mechanical stretch-induced myocardial stunning. Methods: Closed-chest propofol-anesthetized swine (n = 5) were instrumented with a Swan-Ganz catheter and admittance catheters in the LV and RV for continuous biventricular PV analysis (ADV500; Transonic Scisense, Inc., London, ON, Canada). Cardiac MDCT with iodinated contrast (1 ml/kg at 4 ml/s) was performed before, during, and 30 min after TPO elicited by a 1 h intravenous infusion of phenylephrine (PE; 300 µg/min). Right and left ventricular end-diastolic volume, end-systolic volume, and stroke volume were calculated simultaneously with each modality. Load-independent systolic function was derived from biventricular PV loops collected during inferior vena cava occlusion at baseline and 30 min after PE. Results: PE elicited a significant rise in LV pressure and RV pressure that normalized 30 min after the end of the infusion period. Biventricular PV analysis demonstrated a significant increase in LV and RV end-diastolic volume and end-systolic volume during PE that normalized in the RV, but not LV, 30 min after cessation of PE. These changes were confirmed by contrast-enhanced cardiac MDCT-derived measurement of ventricular volumes, with no significant differences between PV and MDCT at any timepoint. Persistent LV dilatation after PE was accompanied by a reduction in load-dependent (dP/dtmax) and load-independent (ESPVR and PRSW) parameters of LV systolic function, reflecting stretch-induced stunning following a ~6-fold rise in LV end-diastolic pressure during PE. This was not observed in the RV, as load-dependent and load-independent parameters of RV systolic function were preserved following PE-induced TPO. Conclusions: Biventricular PV analysis is feasible in swine and provides accurate continuous measurement of ventricular volumes compared with intermittent contrast-enhanced cardiac MDCT. Employing this approach during transient PE infusion demonstrated persistent chamber dilatation and systolic dysfunction in the LV, but not RV, consistent with stretch-induced stunning caused by an acute elevation in preload. The absence of stretch-induced stunning in the RV may be linked to inherent differences in compliance relative to the LV, as well as a diminished pressor response to PE in the pulmonary vs. systemic circulation. The data included in this manuscript were originally shared with the scientific community via two peer-reviewed abstracts referenced within.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».