SAT-427 Bioequivalence Study between 5 mg of Hydrocortisone Solution (ET-400) versus Hydrocortisone Oral Granules (Alkindi Sprinkle)
Notice bibliographique
Résumé
Abstract Disclosure: B. Seo: Eton Pharmaceuticals. M.L. Freedman: Eton Pharmaceuticals. I. Hoos: Eton Pharmaceuticals. D. Radosavljevic: Eton Pharmaceuticals. A. Christensen: Eton Pharmaceuticals. Background: Treatment of adrenal insufficiency in children requires precise hydrocortisone (HC) dosing. Since the discontinuation of Cortef oral suspension, oral dosing options for this population are limited. Current Endocrine Society guidelines for primary adrenal insufficiency suggest dosing as low as 8 mg/m2/day split into 3 doses. The guidelines also recommend against using a compound pharmacy. Precise HC dosing is important because adverse outcomes including adrenal crisis can result from too little HC. Too high HC dosing can also cause detrimental effects, including Cushinoid sequela. An HC oral solution (HOS) was developed to assist with dosing accuracy in children to prevent complications that may arise from under- or overdoing of HC in pediatric, adrenal insufficient patients. Objective: This study investigated if a novel HOS is bioequivalent to a known, FDA-approved, oral HC formulation, also designed for pediatric patients, hydrocortisone oral granules (HOG). Methods: A single-center, open-label, randomized, two-period, crossover, single-dose, bioequivalency study between 5 mg HOS, 1 mg/mL, and 5 mg HOG in dexamethasone (DM)-suppressed healthy adults was conducted. Subjects were administered 4 mg DM 10 hr prior to HC administration. Subjects also fasted for 10 hr prior to HC administration. PK blood draws were conducted over 13 hr, beginning at 1 hr prior to HC administration. PK variables were determined for measured HC using a non-compartmental approach. Subjects were randomized to one of two conditions. Subjects were administered a single dose of 5 mg HOS or HOG. After a 7-day washout, subjects were administered the other treatment. The 2 HC formulations were considered bioequivalent if the 90% CI of the baseline adjusted HC AUCt, AUCinf, and Cmax were within 80 - 125%. Results: 36 subjects were recruited and enrolled in the study. 34 subjects completed the study. 2 subjects were discontinued because of an AE (fever and COVID-19 infection, respectively). The mean differences were: • * AUCt difference was 97.6% (390.7 vs 395.8 hr*ng/mL HOS to HOG, respectively) • * AUCinf difference was 99.4% (456.5 vs 455.8 hr*ng/mL HOS to HOG, respectively) • * Cmax difference was 104.7% (158.6 vs 152.8 ng/mL HOS to HOG, respectively) The study drugs were generally well-tolerated by the healthy DM-suppressed, fasted subjects. There were no serious AEs. None of the AEs compromised the subject’s safety or impacted the study results. Conclusion: This study confirms that HOS and HOG are bioequivalent in DM-suppressed, healthy, fasted adult subjects. Overall, the study medications were well tolerated in this population. Presentation: Saturday, July 12, 2025
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,002 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».