Impact of Asthma Severity and Exacerbation Frequency on Burden of Disease Related Costs in Finland
Notice bibliographique
Résumé
Mariann I Lassenius,1 Juhani Aakko,1 Sara Hallberg,2 Mary Dillon,3 Kaisa Nieminen,4 Hannu Kankaanranta,5– 7 Arja Viinanen,8,9 Paula Kauppi,10 Lauri Lehtimäki5,11 1Medaffcon Oy, Espoo, Finland; 2Health Economics, AstraZeneca Nordics, Gothenburg, Sweden; 3Health Economics, AstraZeneca Nordics, Espoo, Finland; 4Medical Affairs, AstraZeneca Nordics, Espoo, Finland; 5Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; 6Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland; 7Department of Internal Medicine and Clinical Nutrition, Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; 8Department of Pulmonary Diseases, Turku University Hospital, Turku, Finland; 9Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland; 10Department of Pulmonary Diseases, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; 11Allergy Centre, Tampere University Hospital, Tampere, FinlandCorrespondence: Lauri Lehtimäki, Allergy Centre, Tampere University Hospital, Tampere, 33521, Finland, Email lauri.lehtimaki@tuni.fiPurpose: Evaluating productivity loss and healthcare costs among working-aged individuals with asthma is critical for comprehending the economic burden and guiding healthcare policy decisions. An optimized care of asthma could result in substantial societal benefits by improving workforce participation and reducing healthcare resource use. Recent data on the impact of both asthma severity and exacerbation frequency on overall costs are scarce.Patients and Methods: In this retrospective study from Finland, 89,606 working aged patients with asthma were followed from national registers for four years from 2017 to 2020 with the objective to assess the impact of asthma severity and exacerbation frequency on the overall costs arising from direct healthcare resource utilization (visits and drug purchases) and productivity loss (long term sick leaves and disability pensions) with gamma regression models.Results: Severe asthma, noted in 10% of patients, increased healthcare resource utilization and productivity loss costs by 30% and frequent exacerbations, noted in 13% of patients, by 25%, independently of each other and of age, sex and Charlson comorbidity index. The annual overall cost per patient was € 14,359 for severe asthma with frequent exacerbations, followed by € 11,802 in those with non-severe asthma and frequent exacerbations. Most costs were related to productivity losses (60%) compared to direct healthcare costs (40%). The prevalence of asthma increased from 2.7% to 3.0% over the four-year period, an increase was also observed in the subgroup of those with severe asthma.Conclusion: A substantial disease burden associated with frequent exacerbations in both patients with asthma and severe asthma leads to increased productivity loss and direct healthcare costs. The estimated the total annual cost of working-aged patients with asthma was € 715 million in Finland, with 25% of additional costs associated with frequent exacerbations, indicating the potential savings that could be achievable through improved disease control.Plain Language Summary: Why was the study done?The study aimed to understand the economic burden of asthma in relation to disease severity and exacerbation frequency among working-aged individuals in Finland.What did the researchers find?The total annual cost of asthma for working-age patients in Finland was estimated at € 715 million. Patients with severe asthma had 30% higher annual healthcare and productivity loss costs, compared to those with non-severe asthma. Frequent exacerbations also increased annual costs by 25%, irrespective of asthma severity. The annual cost per patient was highest for those with severe asthma and frequent exacerbations (€ 14,359), followed by those with non-severe asthma and frequent exacerbations (€ 11,802). Most costs (60%) were related to productivity losses, with direct healthcare costs making up the remaining 40%.What do the results mean?The study highlights that the significant economic burden of asthma is driven by exacerbation frequency, suggesting that better disease control could lead to significant savings and enhance workforce participation.Keywords: asthma, burden of disease, direct costs, exacerbations, productivity loss, severe asthma
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,007 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,002 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,002 | 0,001 |
| Science ouverte | 0,001 | 0,002 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».