Effects of Rapid Maxillary Expansion on Serum Insulin-Like Growth Factor I and Pharyngeal Airway in a Prepubertal Population with Maxillary Constriction
Notice bibliographique
Résumé
Introduction: Rapid maxillary expansion (RME) is a common treatment in orthodontics to correct transverse maxillary deficiencies manifested in posterior crossbites. Maxillary expansion improves the upper airway morphology by causing lateral movement of the walls of the nasal cavity which could potentially contribute to the improvement of airflow. However, it is unclear whether there is an overall increase in the pharyngeal volume after treatment. Adenotonsillar hypertrophy has been identified as a potential cause of mouth breathing in children, which, when resected with surgery, has been shown to promote growth through the increase of IGF-1, a potent hormone responsible for growth and development.(Nosetti et al. 2023) Currently, there have been no studies that have determined the effect of RME on serum concentrations of IGF-1. The objectives of this study are to determine the effect of RME on the pharyngeal volume as well as serum IGF-1 concentrations in prepubertal children with a maxillary transverse discrepancy over a period of 12 months. Materials and Methods: Forty-three individuals between the ages of 6 and 12 with maxillary skeletal constriction presented in unilateral or bilateral crossbite and crossbite tendency were selected. They were of prepubertal status and void of any medical conditions. The control group consisted of children who did not undergo skeletal expansion, whereas the treatment group received the rapid maxillary expansion with a hyrax appliance. Blood was drawn and CBCTs were taken at the start of the trial (T0) and approximately 12 months after acquiring the first set of data (T1). Blood samples were acquired and analyzed for IGF-1 levels the same day by a commercial laboratory, DynaLife Medical Labs (Edmonton, Canada). Digital Imaging and Communication in Medicine (DICOM) format files were generated from T0 and T1 CBCT scans which were subsequently imported and analyzed by the Slicer© software. Results: No statistically significant effect of maxillary expansion achieved on serum levels of IGF-1 and airway volume due to the p-values being greater than 0.05. The mean difference in IGF-1 levels were 39.2ug/L and 74.2ug/L in the control and treatment groups, respectively. The mean change in airway volumes for the control and treatment group, respectively, were 9299.6mm3 and 12231.9 mm3. Mean difference in IMW for the control and expander group were 0.36mm and 4.17mm. Conclusion: The treatment group did not experience an increase in pharyngeal volume when compared to the control group. Similarly, RME did not produce an increase serum IGF-1 in the treatment group when compared to the control group as well. Therefore, the findings of this research suggest that RME does not produce significant changes in the pharyngeal volume and may not increase IGF-1 levels in children. However, due to sample size and imaging protocols, future studies are required to obtain a more definitive conclusion in this area of study.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».