Abstract B010: Building a global research nextwork focusing on etiology for early-onset colorectal cancer (EOCRC): findings from the Fight Colorectal Cancer 2025 Barcelona Think Tank
Notice bibliographique
Résumé
Abstract The rising incidence of early-onset colorectal cancer (EOCRC), which affects individuals under 50, is becoming a significant public health issue, particularly in high- and middle-income countries but now increase in lower income countries. EOCRC often lacks traditional risk factors like family history or hereditary syndromes and is associated with more aggressive tumors, delayed diagnoses, and considerable psychosocial and financial burdens. Due to fragmented data and a lack of large-scale studies, progress in EOCRC research has been limited. In response, Fight Colorectal Cancer (Fight CRC) organized the first-ever Global Think Tank on EOCRC, held in Barcelona, Spain, in June 2025, with the aim of aggregating global data, identifying emerging risk factors, establishing international research collaborations, and creating a sustained, patient-centered scientific network. The Think Tank utilized a hybrid consensus-development model, incorporating epidemiologic synthesis, data analysis, and stakeholder engagement. The event brought together 71 delegates from 18 countries, representing various fields, including molecular biology, oncology, and patient advocacy. Prior to the meeting, global data was gathered through a 36-item patient survey, which garnered 516 responses from 21 countries, an epidemiologic review of EOCRC incidence and mortality, and expert roundtables discussing potential etiologic factors. The two-day meeting was structured to foster interdisciplinary collaboration, with Day 1 focusing on EOCRC epidemiology and patient integration, and Day 2 addressing emerging hypotheses and regional disparities. New, unpublished data revealed that only 15.2% of EOCRC patients were aware that colorectal cancer could occur before 50, while 42% experienced diagnostic delays, often due to clinicians dismissing symptoms based on age. Furthermore, the incidence of EOCRC is rising by 1.5-4.0% annually, with the highest rates observed in New Zealand, Chile, and Puerto Rico. Over 60% of EOCRC cases are located in the rectum or sigmoid colon, and there were no significant sex-based differences in incidence. Real-time consensus polling indicated strong agreement that low awareness is a major barrier to early detection, with 92% of participants in favor of increasing awareness, and 85% emphasizing the role of diet and processed foods as key environmental factors. Five workgroups were formed, focusing on scientific research, epidemiologic tools, biobanking, global sustainability and advocacy, and risk stratification and awareness. These groups have created a 24-month roadmap that includes launching cohort studies, developing a data-sharing platform, establishing biobanks in underrepresented regions, and aligning global advocacy efforts. The meeting concluded with a commitment to ongoing international collaboration, prioritizing patient voices and ensuring equity, diversity, and inclusion. The momentum generated by this meeting sets the stage for future collaborations aimed at reducing EOCRC incidence and improving outcomes for young patients worldwide. Citation Format: Andrea J. Dwyer, Jose Perea, Daniel Buchanan, Rebecca Siegel, Kiran Ilgan, Anjee Q. Davis, Andrew Chan. Building a global research nextwork focusing on etiology for early-onset colorectal cancer (EOCRC): findings from the Fight Colorectal Cancer 2025 Barcelona Think Tank [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: The Rise in Early-Onset Cancers—Knowledge Gaps and Research Opportunities; 2025 Dec 10-13; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(23_Suppl):Abstract nr B010.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,048 | 0,039 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,003 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,006 | 0,004 |
| Communication savante | 0,010 | 0,006 |
| Science ouverte | 0,003 | 0,011 |
| Intégrité de la recherche | 0,009 | 0,013 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,020 | 0,005 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».