Association between Clinical Profile and Short-Term Outcomes in Paediatric Guillain-Barre Syndrome
Notice bibliographique
Résumé
Background: Guillain-Barre Syndrome (GBS) is a leading cause of acute flaccid paralysis in children. Clinical presentation and the nature of treatment significantly influence short-term outcomes. This study aims to assess the association between the clinical profile and short-term outcomes in paediatric GBS. Objective: The objective of this study was to evaluate the association between various clinical presentations, with shortterm outcomes in paediatric Guillain-Barre Syndrome (GBS) Methods: This retrospective observational study included paediatric GBS patients (ages 6 months to 16 years) admitted to a tertiary care hospital in Bangladesh from January 2023 to December 2024. Data were collected on clinical features, electrophysiological subtype, and treatment modality. Short-term outcomes were assessed by using the Hughes GBS Disability Score during discharge and 3 months after discharge. Statistical analysis was done to find out the association between presentation, treatment, and outcomes. Results: Among 45 children the most common clinical features were ascending lower limb weakness (100%), paraesthesia (89%), cranial nerve involvement (13.3%), and respiratory failure (24.4%). 31% were ambulatory. Electrophysiological subtypes included axonal type (84.4%) and demyelinating (15.6%). IVIG was administered to 42.2% of patients in ward and in ICU, while 31% required ICU care. The disease was progressive in 38%. Good outcomes (Hughes 0-3) were found in 47% at discharge and 62.2% after 3 months. Poor outcomes at discharge were significantly associated with progressive disease (OR =1.5, 95% CI: 0.7-3.2, p=0.01) and respiratory failure (OR=1.2, 95% CI: 0.64-2.4, p=0.02). After 3-month follow-up, several factors were found to be significant. The factors were progressive disease (OR = 6.72, 95% CI: 1.75–25.76, p = 0.005), Respiratory failure (OR = 7.4, 95% CI: 1.6–34.2, p = 0.01), respiratory tract infection as a preceding illness (OR = 3.5, 95% CI: 1.0–12.6, p=0.04) and Need for IVIG (OR=4.58 (95% CI: 1.26–16.63, p = 0.02). Conclusion: The presence of progressive disease, respiratory failure, a history of preceding respiratory infection, and those who required intravenous immunoglobulin (IVIG) therapy were found to be significant indicators of poor outcome. Early identification and aggressive management of these risk factors are crucial for improving paediatric GBS outcomes. Northern International Medical College Journal Vol. 16 No. 1-2 July 2024-January 2025, Page 721-727
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,004 | 0,012 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».