An Empirical Comparison among Four Estimation Methods for the Laplace Distribution and Its Potential Application in Medical Research

This study investigates the performance of four parameter estimation methods for the Laplace distribution: Method of Moments (MM), Maximum Likelihood Estimation (MLE), Minimum Chi-Square Estimation using equiprobable cells (MCE-EQ), and Minimum Chi-Square Estimation using Representative Points (MCE-RP). Through comprehensive Monte Carlo simulations with sample sizes ranging from 50 to 400, we compare the root mean squared error (RMSE) of the location (μ) and scale (b) parameter estimates. Our results demonstrate that while MLE remains robust for location estimation, the MCE-RP method consistently outperforms other estimators—including MLE—for the scale parameter, particularly in small to moderate samples. The use of Representative Points, which provide an optimal discretization of the distribution, significantly enhances estimation precision. These findings are especially relevant for medical research, where accurate estimation of variability—such as in biomarker concentration levels or physiological response times—is critical for reliable sample size determination, risk assessment, and clinical decision-making. MCE-RP thus offers a superior, reliable estimator for the Laplace scale parameter, with direct implications for improving statistical inference in applied biomedical studies. Purpose: The purpose of this research is to empirically evaluate and compare the finite-sample performance of four estimation methods for the Laplace distribution’s parameters, with a focus on the novel application of Representative Points in minimum chi-square estimation. This work seeks to bridge the gap between theoretical estimation methods and practical applications, providing applied researchers with a more robust estimation tool when modeling data with Laplace characteristics, such as those commonly encountered in medical and biomedical studies. Methods: We conducted an extensive Monte Carlo simulation study to compare the four estimation methods: MM, MLE, MCE-EQ, and MCE-RP. For each method, we generated independent and identically distributed samples from a standard Laplace distribution (μ=0, b=1) with sample sizes n = 50, 100, 200, and 400. Each scenario was replicated 1,000 times. The performance of each estimator was assessed using the root mean squared error (RMSE) for both μ and b. The MCE-RP method utilized pre-computed Representative Points for the standard Laplace distribution, which were transformed according to preliminary MLE estimates to form an optimal cell structure for chi-square minimization. All nonlinear optimizations required for MCE-EQ and MCE-RP were implemented programmatically. Results: The simulation results indicate that MLE performs best for estimating the location parameter μ across all sample sizes. However, for the scale parameter b, the MCE-RP method consistently yields lower RMSE values compared to MLE, MM, and MCE-EQ. In many cases, particularly for smaller samples, the RMSE of MCE-RP is approximately half that of MLE for b. The advantage of MCE-RP is evident across varying numbers of Representative Points (m = 5, 10, 15, 20), with optimal performance often observed at m = 10 or 15. These findings confirm that MCE-RP provides a more precise and reliable estimator for the scale parameter, making it particularly advantageous in small-sample settings. Contribution: This paper contributes to the statistical methodology for the Laplace distribution by introducing and validating the use of Representative Points within a minimum chi-square estimation framework. The key contributions are: (1) demonstrating that MCE-RP significantly outperforms established methods for estimating the scale parameter; (2) providing empirical evidence that RP-based discretization enhances estimation efficiency, especially in finite samples; (3) offering practical guidance for applied researchers in fields such as medical statistics, where accurate scale estimation is crucial for variability assessment, power analysis, and reliable inference; and (4) laying a methodological foundation for extending the RP approach to other location-scale distributions.

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