The Relationships Between Cochlear Nerve Health and AzBio Sentence Scores in Quiet and Noise in Postlingually Deafened Adult Cochlear Implant Users
Notice bibliographique
Résumé
OBJECTIVES: This study investigated the relationships between the cochlear nerve (CN) health and sentence-level speech perception outcomes measured in quiet and noise in postlingually deafened adult cochlear implant (CI) users. DESIGN: Study participants included 28 postlingually deafened adult CI users with a Cochlear Nucleus device. For each participant, only one ear was tested. Neural health of the CN was assessed at three or four electrode locations across the electrode array using two parameters derived from results of the electrically evoked compound action potential (eCAP). One parameter was the phase locking value (PLV), which estimated neural synchrony in the CN. The other parameter was the sensitivity of the eCAP amplitude growth function (AGF) slope to changes in the interphase gap (IPG) of biphasic electrical pulses (i.e., the IPGE slope ). Speech perception was tested using AzBio sentences in both quiet and a 10-talker babble background noise with +5 dB and +10 dB signal to noise ratios (SNR). IPGE slope and PLV values were averaged across electrodes for each subject, both with and without weighting by the frequency importance function (FIF) of the AzBio sentences. Pearson and Spearman correlations were used to assess the pairwise relationships between the IPGE slope , the PLV, and age. Multiple linear regression models with AzBio score as the outcome and the PLV and the IPGE slope as predictors were used to evaluate the associations between the three variables while controlling for age. RESULTS: The IPGE slope and the PLV demonstrated different patterns with regard to their relationships with electrode location, age, and speech perception. The PLV, but not the IPGE slope , differed significantly across electrodes, where the apical electrodes had larger PLVs (better neural synchrony) than the basal electrodes. The IPGE slope , but not the PLV, was significantly correlated with participant's age, where smaller IPGE slope values (poorer spiral ganglion neuron density) were associated with more advanced age. After controlling for the effect of age, the PLV, but not the IPGE slope , was significantly associated with AzBio scores in the +5 dB SNR condition, where larger PLVs predicted better speech perception. Neither the PLV nor the IPGE slope was significantly associated with AzBio score in quiet or in the +10 dB SNR condition. The result patterns remained the same regardless of whether the mean values of the IPGE slope and the PLV were weighted by the AzBio FIF. The result patterns generally did not change with fitting methods or input/output scales of the AGF slopes. CONCLUSIONS: The IPGE slope and the PLV quantify different aspects of CN health. The positive association between the PLV and AzBio scores in the +5 dB SNR condition suggests that neural synchrony is important for speech perception in adult CI users in challenging listening conditions with a relatively high noise level. The lack of association between age and the PLV indicates that reduced neural synchrony in the CN might not be the primary factor accounting for the greater deficits in understanding speech in noise observed in older CI users, as compared with middle-aged CI users.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».