Sensory and cognitive changes in occupational performance in adults and elderly submitted to neurotoxic chemotherapy
Notice bibliographique
Résumé
Brazil is in a demographic and epidemiological transition, marked by an increase in the number of elderly people and chronic non-communicable diseases (NCDs), such as cancer. Chemotherapy stands out for its effectiveness in the treatment of this disease, but due to its lack of specificity, it can cause adverse effects, among them, Chemotherapy-Induced Peripheral Neuropathy (NPIQ). The aim of this study was to evaluate changes in occupational performance, cognition and sensitivity caused by neurotoxicity in adults and the elderly undergoing potentially neurotoxic chemotherapy. The research was carried out in an adult oncology inpatient unit, located in a public hospital in the interior of Rio Grande do Sul and evaluated eight (n = 8) elderly and five (n = 5) adults. It is a research with a quantitative, longitudinal and descriptive approach. For data collection, a questionnaire about sociodemographic and clinical information was used; the Canadian Occupational Performance Measure (COPM) to assess possible changes as a result of the illness process; the Mini-Mental State Examination (MMSE), the Antineoplastic-Induced Neurotoxicity Questionnaire (QNIA) and the Semmes-Weinstein Monofilaments (MSW) to assess neurotoxicity. The COPM data went through the instrument's own analysis and the other data were plotted in Excel software tables. The descriptive analysis of the data was performed with presentation of mean and standard deviation, after checking the normality curve of the data. The variables assumed non-parametric distribution by the Shapiro- Wilk test, therefore it is necessary to choose non-parametric tests for the discrete variables. Fisher's exact test for categorical variables and the Mann-Whitney test for numerical variables were used for association. The results show that the occupational performance of adults and the elderly have undergone changes, with emphasis on the domains of productivity and leisure. Regarding performance satisfaction, changes occurred in the domains of self-care and productivity. As for cognition, the results show slight changes in mental status, with general improvement between the three phases of collection. However, when analyzing the scores by area, it is observed that the areas of remembering, recording and attention and calculation showed a decline in the score throughout the treatment. As for neurotoxicity, NPIQ affected the sensitivity of adults and the elderly, as all of them report symptoms already in the middle of the treatment, showing a tendency of aggravation in the elderly. The present study contributes to the understanding of changes in occupational performance that the process of illness and neurotoxicity resulting from chemotherapy treatment can cause in the lives of adults and the elderly, with a tendency of aggravation in the elderly. Neurotoxicity can cause disabilities in daily life, impacting quality of life in the short and long term. The novelty of this study in Brazil stands out and, as limiting factors, we highlight the small sample size and the suspension of collections due to the Covid-19 pandemic. The NPIQ presents aspects that have not yet been clarified, which need to be addressed in future research, such as differences in incidence, including after the completion of treatment, risk factors and pharmacological and non-pharmacological treatments.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».