Evaluation of cognitive alterations, mental health and quality of life in adult patients with Sleep Disordered Breathing
Notice bibliographique
Résumé
Introduction: Sleep Disordered Breathing (SDB) can lead to cognitive impairments, mood and can reduce patient´s quality of life. There are different cognitive domains, such as intelligence, memory, attention, language, executive functions, among others. Estimate that cognitive impairment is caused by serious disorders, however, the magnitude of these impairments is not very likely, especially in the mild forms, including Upper Airway Resistance Syndrome (UARS) and Mild Obstructive Sleep Apnea (OSA). Objective: This study aimed to evaluate the cognitive functions, mental health and quality of life in patients with mild SDB. Methods: 52 participants with either genders and with body mass index (BMI) < 35 Kg/m2 were included; between the ages of 25 to 50 years, according to clinical polysomnographic diagnosis of UARS (AHI score < 5 events/hours and RDI score ≥ 5 events/hour with excessive daytime sleepiness (EDS) complaints and Epworth Sleepiness Scale scores (ESS) > 10 and/or the Modified Fatigue Impact Scale scores ≥ 38); Mild OSA (5 events/hour ≤ AHI < 15 events/hour with complains) and control group without diagnosis of Sleep Breathing Disorders and no complains. Participants were allocated into 2 groups: Group 1 – Control group (n = 19) and Group 2 – UARS + mild OSA or mild SDB (n = 33). The evaluations consisted of full-night polysomnography exam (PSG); Epworth Sleepiness Scale (ESS); Pittsburgh Sleep Quality Index (PSQI); Modified Fatigue Impact Scale (MFIS-BR); Functional Outcomes of Sleep Questionnaire (FOSQ); application of cognitive instruments to assess memory, attention, executive functions; application of Beck Depression Inventory; Beck Anxiety Inventory; Lipp`s Stress Symptoms Inventory for Adults (ISSL) and finally anthropometric measurements were also collected. Results: Regarding the sleep structure, it was found that the mild SDB group showed higher proportion of the sleep stage N2 and lower proportion of sleep stage N3 when compared to the control group (p= 0,006, p=0,008, respectively). For the cognitive assessment it was observed that patients with mild Sleep Disordered Breathing had a lower performance in the immediate episodic memory domain (p=0,02) with no significant differences in the other cognitive functions evaluated. The mild SDB group showed an increase in the depressive symptoms and in the fatigue score when compared to control group (p = 0,05, p = 0,007, respectively). Conclusions: Mild SDB may be associated with symptoms of depression, fatigue and changes in sleep structure with reduced slow- wave sleep. Cognitive alteration was observed in the domain of verbal episodic memory, however, in the absence of other changes it may not have relevant clinical significance. Interestingly and contrary to our hypothesis, the UARS group showed more cognitive changes, consistently and significantly when compared to mild OSA group, however UARS and mild OSA group did not differ in relation to symptoms of depression, anxiety, stress, fatigue, impact of sleepiness on quality of life, excessive sleepiness and some sleep parameters.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».