The Feasibility and Acceptability of a Remotely Delivered, Combined Exercise Intervention on Cognitive Function in Patients With Breast Cancer Following Chemotherapy: Randomized Controlled Trial (Preprint)
Notice bibliographique
Résumé
BACKGROUND Cognitive impairments, a prevalent quality-of-life concern in breast cancer (BC), are particularly pronounced in women having undergone adjuvant chemotherapy. These impairments—affecting executive function, attention, and processing speed—are often underdiagnosed, with no established treatments. Exercise is a potential intervention to mitigate cancer-related cognitive impairment (CRCI). Since virtual care delivery is feasible, remotely delivered exercise interventions for CRCI management in patients with BC may be explored. OBJECTIVE We examined the feasibility of an 8-week remotely delivered combined exercise program (aerobic+resistance training) compared to a stretching and toning active control in postchemotherapy patients with BC. METHODS Patients with BC who completed adjuvant chemotherapy within 48 months were recruited across Canada from February to July 2023. The combined exercise group engaged in unsupervised aerobic exercise (30 minutes, thrice per week), supervised group-based resistance training (30 minutes, twice per week via Zoom [Zoom Communications, Inc]), and one recorded class weekly, supplemented with 4 biweekly behavioral counseling sessions. The active control group participated in low-intensity balance and flexibility classes (30 minutes, twice per week live, once per week recorded). Feasibility was assessed via enrollment, adherence, attrition, measurement completion, adverse events, and participant satisfaction; cognitive function, using the National Institutes of Health Toolbox Cognition Battery Remote Administration (V2) at baseline and post intervention. RESULTS Twenty-one participants (mean age 51.6, SD 7.2 years; 11.8, SD 12.9 months since treatment) were randomized to the combined exercise (n=10) or the active control (n=11) group. Final analyses included 18 participants (mean age 51.9, SD 7.4 years; mean months since treatment 12.6, SD 13.5) with 9 participants in each group (51.2% enrollment rate; 14.3% attrition; no adverse events). Measurement completion rates were 85.7% and participants reported high satisfaction with the intervention, indicating minimal burden. Adherence rates for exercise classes were 70.8% in both groups. Adherence to behavioral counseling sessions was 77.5% (combined exercise group only). There were no significant differences in objectively measured cognitive function, but small-to-medium effect size improvements were observed in objectively measured episodic memory (mean difference 5.33, 95% CI –12.5 to 23.2; ηp²=0.03), working memory (mean difference 8.17, 95% CI –4.2 to 20.6; ηp²=0.12), executive function updating (mean difference –394.35, 95% CI –1035.67 to 246.96 ms; ηp²=0.07), and immediate memory and verbal learning (mean difference +3.22, 95% CI –2.0 to 8.5; ηp²=0.12), trending toward the multicomponent exercise group vs the active control group. In contrast, small-to-medium effect size improvements were observed in the Oral Reading Recognition Test (mean difference –9.65, 95% CI –22.9 to 3.5; P=.14; ηp²=0.14) and Picture Vocabulary Test (mean difference –2.48, 95% CI –5.2 to 0.3, P=.07; ηp²=0.20), trending toward the active control group. CONCLUSIONS A remotely delivered combined exercise intervention is feasible and may improve CRCI in patients with BC. Larger randomized controlled trials are warranted to confirm its efficacy in enhancing cognitive function and quality of life in this population. CLINICALTRIAL ClinicalTrials.gov NCT05704855; https://clinicaltrials.gov/study/NCT05704855
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,002 | 0,003 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,002 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,009 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».