Pronalaženje dokaza o učinkovitosti i sigurnosti suplementacije antioksidativnim vitaminima u prevenciji i usporavanju progresije katarakte povezane sa starenjem
Notice bibliographique
Résumé
Objectives: The aim of this study was to evaluate the available RCTs and systematic reviews regarding the efficacy and safety of antioxidant vitamin supplementation in preventing and slowing the progression of age-related cataract and to examine if we could find enough evidence for this. Materials and methods: The Cochrane systematic review “Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract” was used as a base and according to its inclusion criteria we tried to find RCTs and systematic reviews published after it, yielding additional proof of the safety and efficacy of antioxidant vitamin supplementation regarding age-related cataracts. We searched PubMed, CENTRAL and DARE. After the search, we made a quality assessment of the systematic review using RAMSTAR. Results: The Cochrane systematic review involved nine trials, with 117,272 participants overall and an age range of ≥ 35 years. The trial follow-up ranged from 2.1 to 12 years and the trials were conducted in Italy, Finland, the United Kingdom, Australia, India and the United States. The antioxidant vitamins were dosed above the recommended daily allowance. No evidence was found supporting that antioxidant vitamin supplementation could reduce the risk of progression of cataract, cataract development, cataract extraction or that it could slow the loss of visual acuity. No evidence of effect of supplementation of beta-carotene in reducing the risk of cataract could be found in the pooled analysis (RR 0.99, 95%, CI 0.91-1.08; number of participants: 57,703) nor could be evidence found for a reduction of the risk of cataract extraction (RR 1.00, 95% CI 0.91-1.10; number of participants: 86,836). For the supplementation with vitamin E no risk reduction in cataract incidence could be found in the pooled analysis either (RR 0.97, 95% CI 0.91-1.04; number of participants: 50,059) or of cataract extraction (RR 0.98, 95% CI 0.91 - 1.05; number of participants: 83,956). 7.4 - 15.8% of patients on beta-carotene developed hypercarotenodermia (yellowing of skin). Only one additional RCT was found involving 11,267 exclusively male participants from the United States, Canada and Puerto Rico, with an age range of 50 years and older. Only part of this RCT was of interest for us, the part concerning supplementation with vitamin E. It lasted 5.6 years. Conclusion: Not enough evidence could be found to prove the safety and efficacy of supplementation with antioxidant vitamins for the slowing and the prevention of age-related cataract. Further research among non-well-nourished populations or well-nourished populations but regarding antioxidant blood levels rather than supplementation could be conducted in the future.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».