Childhood ganglioneuroma
Notice bibliographique
Résumé
Background Ganglioneuroma (GN) is an uncommon benign neuroblastic tumor. They can arise de novo or from spontaneous or therapy-induced differentiation. Surgical excision is the treatment of choice with no role for chemotherapy. Ganglioneuroblastoma (GNB) is the intermediate part of the spectrum. Ganglioneuroblastoma intermixed (GNBi) is always favorable with many studies relating its behavior and management to GN. GN can be the dominant pathology of GNB on a core or an open biopsy material. Resection specimen can reveal immature neuroblasts and/or neuropil reclassifying the diagnosis to malignant GNB, whether nodular or intermixed, with further re-evaluation for risk stratification and biologic state. Aim The aim of this study was to evaluate the clinicopathologic features and outcome of ganglioneuromatous tumor. The study also included cases that were initially diagnosed as GN on a biopsy material and was reclassified as GNB on resection or open biopsy material. The study highlights the impact of missampling on reclassification with comparison of clinicopathologic features and outcome of the latter. Patients and methods The study included cases that were diagnosed as GN at the Children’s Cancer Hospital Egypt 57357 during the period from July 2007 to July 2017. The study also included cases that were diagnosed as GN on biopsy material and was reclassified as GNB. Results A total of 1429 patients were diagnosed as having neuroblastic tumors, of which 29 (2.02%) patients were diagnosed as GN. GN patients had an age range from 31.2 to 147.6. Men dominated over women (72.4%), extra-adrenal location being 65.5%. Six (20.7%) patients had intraspinal extension. As for surgery, 13 (86.6%) patients had complete mass resection and two (13.3%) patients had incomplete removal. Fourteen (48.3%) patients did not have surgery. GN cases that were reclassified to GNB had an age range from 19.2 to 199.2 months. Women (79.2%) were more than men (20.8%). Twenty-one (87.5%) patients had extra-adrenal location. Ten (41.6%) patients showed intraspinal extension. Fourteen (58.3%) cases had total mass resection and 10 (41.7%) had incomplete mass resection. None of the examined bone marrow cases showed infiltration by malignant cells nor had NMYC gene amplification. Follow-up for the two groups were excellent with 3-year overall survival of 100% for GN patients, 100% for GNBi cases, and 95.8% for all GNB cases. Conclusion GN has very good outcome with or without surgical removal of the mass. GNBi also presents nearly the same clinicopathologic features, with same favorable outcome even in cases showing incomplete resection.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».