The effects of gestational weight gain on vitamin D status of the neonate
Notice bibliographique
Résumé
Introduction: Vitamin D deficiency is common in pregnant women and subsequently, their offspring can be born with low status. Growing evidence suggests that vitamin D requirements may be weight dependent, due to its liposolubility, and/or due to volume dilution effects in larger individuals. These mechanisms are applicable to pregnant women, as the largest constituents of gestational weight gain (GWG) are increasing fat stores and fluid accumulations. Associations between GWG and vitamin D status of neonates and their mothers has not been extensively studied.Objectives: Primary: To test for relationships between maternal GWG and vitamin D status of their newborn infant. Secondary: To explore relationships between GWG and maternal vitamin D status, pre-gravid body mass index (BMI) and vitamin D status of the neonate and mother.Methodology: Healthy mother-infant pairs (n=59) from the greater Montreal area were recruited 24-36 hours post-partum (clinicaltrials.gov: NCT02563015). A demographic survey was administered to participants and dietary intake of vitamin D was assessed using a validated food frequency questionnaire (FFQ) to reflect pregnancy. Blood samples were collected from mothers and their infants to assess serum 25-hydroxyvitamin D [25(OH)D] concentrations using a chemiluminescent assay, Liaison auto-analyzer (Diasorin Inc.). Infant and maternal anthropometrics were obtained from medical charts. Data were analyzed in three groups: mothers who had inadequate (n=17), adequate (n=18) or excessive (n=24) GWG as per Health Canada’s recommendations. A mixed model ANOVA and a linear regression were performed (SAS, v9.3), with GWG and infant sex as fixed effects. For the three GWG categories, p<0.05 after adjustment for multiple comparisons using Scheffe’s test was considered statistically significant. Data are mean ±standard deviation unless otherwise noted.Results: Maternal pre-gravid body mass index was 24.7 ± 5.1 kg/m2, infant birth weight-for-age Z-score was 0.2 ± 0.8 and 54% were male. Infant serum 25(OH)D concentration was 40.9 ± 18.9 nmol/L, with 29% <30 nmol/L and 42% <50 nmol/L; status did not differ between sexes. Maternal serum 25(OH)D concentration was 62.7 ± 25.8 nmol/L with 7% <30 nmol/L and 35% <50 nmol/L. Maternal and infant serum 25(OH)D were significantly related (r=0.74, p<0.0001). Mean serum 25(OH)D concentrations were significantly lower between GWG groups for infants born to mothers with excessive compared to adequate GWG (ANOVA p=0.02). Mothers’ concentrations did not differ amongst GWG categories. In regression analysis (R^2=0.57), neonatal serum 25(OH)D concentration was 15.2 nmol/L higher when born to white compared to non-white mothers and 4.2 nmol/L higher for each 10 nmol/L increment in maternal serum 25(OH)D. Significant correlations between pre-gravid BMI and serum 25(OH)D concentration were only found in neonates (r=-0.34, p=0.008; maternal model: r=0.24, p=0.06). Further investigation accounting for covariates using a mixed model ANOVA and linear regression showed no differences between BMI categories for mothers or infants.Conclusion: These results suggest that mothers with excessive GWG are more likely to have infants born with vitamin D insufficiency, independent of being non-white or having lower vitamin D status. Additionally, a large proportion of infants (71%) were vitamin D insufficient at birth despite the fact that more than 60% of our mothers met or exceeded the RDA of 600 IU of vitamin D daily during pregnancy. Further research on the role of GWG on vitamin D status during pregnancy, as well as a revision of dietary recommendations for this population, are warranted.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».